ZFIN ID: ZDB-GENE-081104-519
Gene Name: cytochrome P450, family 27, subfamily A, polypeptide 7
Gene Symbol: cyp27a7    Nomenclature History

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Previous Name: si:dkeyp-68f9.9

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have cholesterol 26-hydroxylase activity and vitamin D3 25-hydroxylase activity. Predicted to be involved in calcitriol biosynthetic process from calciol; cholesterol metabolic process; and oxidation-reduction process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:402831 (1),  Ensembl(GRCz11):ENSDARG00000033802 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9857 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18959 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp27a7 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp27a7 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component mitochondrion (more)
    Molecular Function heme binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp27a7-201 (1)    Ensembl 2374
    ncRNA cyp27a7-002 (1)    Ensembl 881
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp27a7 No data available
    MARKER RELATIONSHIPS
    cyp27a7 Contained in: [BAC] DKEYP-68F9 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002663399 (1) 2519 nt
    Genomic GenBank:BX001051 (1) 213486 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q7SXE6 (1) 531 aa
    Sequence Information (all 9)
    ORTHOLOGY for cyp27a7 ( Chr: 9 )
    CITATIONS (17)