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General Information
ZIRC
ZFIN ID: ZDB-GENE-081104-511
Gene Name: cytochrome P450, family 27, subfamily A, polypeptide 1, gene 2
Gene Symbol: cyp27a1.2    Nomenclature History

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Previous Name: si:dkeyp-68f9.10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have heme binding activity; iron ion binding activity; and oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Human ortholog(s) of this gene implicated in cerebrotendinous xanthomatosis. Orthologous to human CYP27A1 (cytochrome P450 family 27 subfamily A member 1).
Genome Resources: Alliance (1),  Gene:795106 (1),  Ensembl(GRCz11):ENSDARG00000069186 (1)
GENE EXPRESSION
All Expression Data: 2 figures from Lin et al., 2011
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6152 Point Mutation Unknown Missense, Splice Site ENU
sa14111 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21546 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27447 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp27a1.2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp27a1.2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Molecular Function heme binding (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp27a1.2-201 (1)    Ensembl 1818
    ncRNA cyp27a1.2-002 (1)    Ensembl 882
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp27a1.2 No data available
    MARKER RELATIONSHIPS
    cyp27a1.2 Contained in: [BAC] DKEYP-68F9 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001333968 (1)
    Genomic GenBank:BX001051 (1) 213486 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E9QJ06 (1) 522 aa
    Sequence Information (all 6)
    ORTHOLOGY for cyp27a1.2 ( Chr: 9 )
    CITATIONS (11)