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ZIRC
ZFIN ID: ZDB-GENE-081104-419
Gene Name: WASP actin nucleation promoting factor a
Gene Symbol: wasa    Nomenclature History

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Previous Names: si:dkey-48j7.6, wasp2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in several processes, including actin cortical patch assembly; actin cortical patch localization; and actin filament-based movement. Predicted to localize to the actin cortical patch and actin filament. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Is expressed in hematopoietic system; leukocyte; neuromast; and thrombocyte. Orthologous to human WAS (WASP actin nucleation promoting factor).
Genome Resources: Alliance (1),  Gene:571256 (1),  Ensembl(GRCz11):ENSDARG00000015149 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34409 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wasa N/A 3
    MO2-wasa N/A 2
    MO3-wasa N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH wasa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    thrombocytopenia Alliance Thrombocytopenia, X-linked 313900
    Thrombocytopenia, X-linked, intermittent 313900
    Wiskott-Aldrich syndrome Alliance Wiskott-Aldrich syndrome 301000
    Neutropenia, severe congenital, X-linked 300299
    DISEASE ASSOCIATED WITH wasa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin filament organization (more)
    Cellular Component actin cortical patch (more)
    Molecular Function actin binding (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wasa-201 (1)    Ensembl 2345
    ncRNA wasa-002 (1)    Ensembl 492
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wasa No data available
    MARKER RELATIONSHIPS
    wasa Contained in: [BAC] DKEY-48J7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_694827 (1)
    Genomic GenBank:CR450776 (1) 126881 bp
    Select Tool
    Polypeptide UniProtKB:F1Q6U7 (1) 630 aa
    Sequence Clusters UniGene:156098 (1)
    Sequence Information (all 15)
    ORTHOLOGY for wasa ( Chr: 8 )
    CITATIONS (17)