Gene
adamts10
- ID
- ZDB-GENE-081104-414
- Name
- ADAM metallopeptidase with thrombospondin type 1 motif, 10
- Symbol
- adamts10 Nomenclature History
- Previous Names
-
- si:dkey-45m5.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to localize to extracellular matrix. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Brunet et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Weill-Marchesani syndrome | Alliance | Weill-Marchesani syndrome 1, recessive | 277600 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR001590 | Peptidase M12B, ADAM/reprolysin |
Domain | IPR002870 | Peptidase M12B, propeptide |
Domain | IPR010294 | ADAM-TS Spacer 1 |
Domain | IPR010909 | PLAC |
Domain | IPR041645 | ADAM cysteine-rich domain 2 |
Family | IPR013273 | ADAMTS/ADAMTS-like |
Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
Repeat | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
Domain Details Per Protein
Protein | Length | ADAM cysteine-rich domain 2 | ADAMTS/ADAMTS-like | ADAM-TS Spacer 1 | Metallopeptidase, catalytic domain superfamily | Peptidase M12B, ADAM/reprolysin | Peptidase M12B, propeptide | PLAC | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B0S6F1
|
1108 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
adamts10-201
(1)
|
3978 nt |
Interactions and Pathways
No data available
Plasmids
No data available