ZFIN ID: ZDB-GENE-081104-376
Gene Name: si:dkey-220o5.5
Gene Symbol: si:dkey-220o5.5    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have SH2 domain binding activity and SH3 domain binding activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of interleukin-8 production; and regulation of interleukin-6 production. Predicted to localize to the cytosol.
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000099211 (1)

Nomenclature Note: This gene is derived from the zebrafish genome sequencing and annotation project. When more is known about the gene, the current nomenclature will be replaced with more traditional zebrafish gene nomenclature. The prefix 'si:' indicates that this gene is represented by annotated genomic sequence from the Sanger Institute.

GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34480 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34481 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH si:dkey-220o5.5 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH si:dkey-220o5.5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of signal transduction (more)
    Cellular Component cytoplasm (more)
    Molecular Function signaling adaptor activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001849 Pleckstrin homology domain
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Family IPR030113 Actin-filament associated protein
    Family IPR030115 Actin filament-associated protein 1-like 2
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA si:dkey-220o5.5-201 (1)    Ensembl 860
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM si:dkey-220o5.5 No data available
    MARKER RELATIONSHIPS
    si:dkey-220o5.5 Contained in: [BAC] DKEY-220O5 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:CR931937 (1) 174451 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IG21 (1) 286 aa
    ORTHOLOGY for si:dkey-220o5.5 ( Chr: 8 )
    CITATIONS (10)