ZFIN ID: ZDB-GENE-081104-30
Gene Name: gamma-aminobutyric acid type A receptor subunit alpha5
Gene Symbol: gabra5    Nomenclature History

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Previous Name: si:dkey-93p24.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to localize to several cellular components, including GABA-A receptor complex; dendrite membrane; and postsynapse. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in bipolar disorder; early infantile epileptic encephalopathy; and mental depression. Orthologous to human GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5).
Genome Resources: Alliance (1),  Gene:799124 (1),  Ensembl(GRCz11):ENSDARG00000070730 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7585 Point Mutation Unknown Missense ENU
sa8377 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gabra5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Epileptic encephalopathy, early infantile, 79 618559
    DISEASE ASSOCIATED WITH gabra5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function extracellular ligand-gated ion channel activity (more)
    GO Terms (all 29)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gabra5-202 (1)    Ensembl 1853
    ncRNA gabra5-002 (1)    Ensembl 785
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM gabra5 No data available
    MARKER RELATIONSHIPS
    gabra5 Contained in: [BAC] DKEY-93P24 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005166082 (1) 3378 nt
    Genomic GenBank:BX664715 (1) 231173 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E9QE70 (1) 453 aa
    Sequence Information (all 18)
    ORTHOLOGY for gabra5 ( Chr: 6 )
    CITATIONS (21)