ZFIN ID: ZDB-GENE-081104-294
Gene Name: cyclin-dependent kinase 12
Gene Symbol: cdk12    Nomenclature History

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Previous Names: si:ch73-79d13.1, wu:fa01h10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have several functions, including cyclin binding activity; protein serine/threonine kinase activity; and transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in phosphorylation of RNA polymerase II C-terminal domain; positive regulation of transcription elongation from RNA polymerase II promoter; and transcription elongation from RNA polymerase II promoter. Predicted to localize to cyclin/CDK positive transcription elongation factor complex and nuclear chromatin. Orthologous to several human genes including CDK12 (cyclin dependent kinase 12).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000063726 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1307 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23419 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29141 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cdk12 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdk12 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein phosphorylation (more)
    Cellular Component chromosome (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdk12-201 (1)    Ensembl 5821
    cdk12-202 (1)    Ensembl 579
    cdk12-203 (1)    Ensembl 898
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdk12 No data available
    MARKER RELATIONSHIPS
    cdk12 Contained in: [BAC] CH73-79D13 (1), CH73-223G8 (1)
    cdk12 Encodes: [EST] fa01h10
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:AA495256 (1) 397 nt
    Genomic GenBank:CU658288 (1) 73567 nt
    Select Tool
    Polypeptide UniProtKB:F1R6Y1 (1) 1293 aa
    Sequence Information (all 7)
    ORTHOLOGY for cdk12 ( Chr: 19 )
    CITATIONS (17)