Gene
pex6
- ID
- ZDB-GENE-081104-252
- Name
- peroxisomal biogenesis factor 6
- Symbol
- pex6 Nomenclature History
- Previous Names
-
- si:ch73-197b13.2
- si:ch73-197b13.3
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable ATP hydrolysis activity. Predicted to be involved in protein import into peroxisome matrix and protein unfolding. Predicted to act upstream of or within peroxisome organization. Predicted to be located in photoreceptor outer segment. Predicted to be active in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in Heimler syndrome 2; Peroxisome biogenesis disorder 4B; and peroxisome biogenesis disorder 4A. Orthologous to human PEX6 (peroxisomal biogenesis factor 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Heimler syndrome 2 | Alliance | Heimler syndrome 2 | 616617 |
| peroxisome biogenesis disorder 4A | Alliance | Peroxisome biogenesis disorder 4A (Zellweger) | 614862 |
| Peroxisome biogenesis disorder 4B | Alliance | Peroxisome biogenesis disorder 4B | 614863 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003960 | ATPase, AAA-type, conserved site |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR041569 | AAA ATPase, AAA+ lid domain |
| Domain | IPR047533 | Peroxisomal biogenesis factor 6, second ATPase domain |
| Family | IPR050168 | AAA ATPase domain-containing protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA ATPase, AAA+ lid domain | AAA+ ATPase domain | AAA ATPase domain-containing protein | ATPase, AAA-type, conserved site | ATPase, AAA-type, core | Peroxisomal biogenesis factor 6, second ATPase domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QMB0 | InterPro | 1071 | |||||||
| UniProtKB:A0A8M9PSM5 | InterPro | 564 | |||||||
| UniProtKB:A0A8M9P4U9 | InterPro | 507 |
Interactions and Pathways
No data available
Plasmids
No data available