fdft1

ID

ZDB-GENE-081104-242

Name

farnesyl-diphosphate farnesyltransferase 1

Symbol

fdft1 Nomenclature History

Previous Names

si:ch73-107c13.2

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable squalene synthase [NAD(P)H] activity. Predicted to be involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Predicted to act upstream of or within lipid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brain. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fdft1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Squalene synthase deficiency	618156

Associated With fdft1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019845	Squalene/phytoene synthase, conserved site
Domain	IPR033904	Trans-isoprenyl diphosphate synthases, head-to-head
Family	IPR002060	Squalene/phytoene synthase
Family	IPR006449	Squalene synthase-like
Family	IPR044844	Trans-isoprenyl diphosphate synthases, eukaryotic-type
Homologous_superfamily	IPR008949	Isoprenoid synthase domain superfamily