ZFIN ID: ZDB-GENE-081104-242
Gene Name: farnesyl-diphosphate farnesyltransferase 1
Gene Symbol: fdft1    Nomenclature History

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Previous Name: si:ch73-107c13.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have farnesyl-diphosphate farnesyltransferase activity and squalene synthase activity. Predicted to be involved in cholesterol biosynthetic process and farnesyl diphosphate metabolic process. Predicted to localize to endoplasmic reticulum membrane. Orthologous to human FDFT1 (farnesyl-diphosphate farnesyltransferase 1).
Genome Resources: Alliance (1),  Gene:571911 (1),  Ensembl(GRCz11):ENSDARG00000101062 (1)
GENE EXPRESSION
All Expression Data: Fig. 5 from DeRossi et al., 2016
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028288Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6657 Point Mutation Unknown Splice Site ENU
    sa37183 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fdft1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Squalene synthase deficiency 618156
    DISEASE ASSOCIATED WITH fdft1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process biosynthetic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function farnesyl-diphosphate farnesyltransferase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fdft1-201 (1)    Ensembl 726
    fdft1-202 (1)    Ensembl 1564
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fdft1 No data available
    MARKER RELATIONSHIPS
    fdft1 Contained in: [BAC] CH73-107C13 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001202525 (1) 1392 nt
    Genomic GenBank:CU207296 (1) 98771 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IVV5 (1) 418 aa
    Sequence Information (all 9)
    ORTHOLOGY for fdft1 ( Chr: 20 )
    CITATIONS (23)