ZFIN ID: ZDB-GENE-081104-238
Gene Name: NK3 homeobox 1
Gene Symbol: nkx3-1    Nomenclature History

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Previous Name: si:ch211-67o1.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in sclerotome. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human NKX3-1 (NK3 homeobox 1).
Genome Resources: Alliance (1),  Gene:555375 (1),  Ensembl(GRCz11):ENSDARG00000078280 (2)
GENE EXPRESSION
All Expression Data: Fig. S4 from Kobayashi et al., 2014
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41300 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nkx3-1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nkx3-1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nkx3-1-202 (1)    Ensembl 774
    ncRNA nkx3-1-002 (1)    Ensembl 629
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nkx3-1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tgbac(nkx3-1:gal4-vp16) nkx3-1 GAL4VP16 Danio rerio 1 1
    MARKER RELATIONSHIPS
    nkx3-1 Contained in: [BAC] CH211-67O1 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_677868 (1)
    Genomic GenBank:BX004845 (1) 165089 nt
    Select Tool
    Polypeptide UniProtKB:F6NGH9 (1) 214 aa
    Sequence Information (all 8)
    ORTHOLOGY for nkx3-1 ( Chr: 8 )
    CITATIONS (20)