Gene

cux2b

ID
ZDB-GENE-081104-176
Name
cut-like homeobox 2b
Symbol
cux2b Nomenclature History
Previous Names
  • cux2
  • si:ch211-218i18.2 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Predicted to be involved in Golgi vesicle transport and negative regulation of transcription by RNA polymerase II. Predicted to localize to Golgi membrane and nucleus. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Is expressed in eye; hindbrain; and telencephalon. Orthologous to human CUX2 (cut like homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Takano et al., 2011
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Charlton-Perkins et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cux2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 67 Alliance Developmental and epileptic encephalopathy 67 618141
Associated With cux2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR003350 CUT domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR010982 Lambda repressor-like, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length CUT domain Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily Lambda repressor-like, DNA-binding domain superfamily
UniProtKB:A0A8M3B1R7 1456
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations