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Gene

lamb2

ID
ZDB-GENE-081030-4
Name
laminin, beta 2 (laminin S)
Symbol
lamb2 Nomenclature History
Previous Names
  • si:dkey-32e6.2
  • sof
  • softy (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable integrin binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including basement membrane assembly; glial cell development; and muscle attachment. Predicted to be located in membrane. Predicted to be part of laminin complex. Is expressed in several structures, including adaxial cell; head; musculature system; nervous system; and solid lens vesicle. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Orthologous to human LAMB2 (laminin subunit beta 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lamb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nephrotic syndrome type 5 Alliance Nephrotic syndrome, type 5, with or without ocular abnormalities 614199
Pierson syndrome Alliance Pierson syndrome 609049
Associated With lamb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR002049 Laminin EGF domain
Domain IPR008211 Laminin, N-terminal
Domain IPR013015 Laminin IV type B
Homologous_superfamily IPR038684 Laminin, N-terminal domain superfamily
Domain Details Per Protein
Protein Length EGF-like domain Laminin EGF domain Laminin IV type B Laminin, N-terminal Laminin, N-terminal domain superfamily
UniProtKB:B7ZDA6 1782
UniProtKB:C8YMC6 115
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations