ZFIN ID: ZDB-GENE-081030-4
Gene Name: laminin, beta 2 (laminin S)
Gene Symbol: lamb2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: si:dkey-32e6.2, sof, softy (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent and integrin binding activity. Involved in several processes, including basement membrane assembly; glial cell development; and muscle attachment. Predicted to localize to laminin complex. Is expressed in several structures, including adaxial cell; head; musculature system; nervous system; and solid lens vesicle. Human ortholog(s) of this gene implicated in Pierson syndrome and nephrotic syndrome type 5. Orthologous to human LAMB2 (laminin subunit beta 2).
Genome Resources: Alliance (1),  Gene:337767 (1),  Ensembl(GRCz11):ENSDARG00000002084 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014343Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10763 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43957 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • te234 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm272a Point Mutation Exon 3 Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tz212 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lamb2
    1
    CRISPR2-lamb2
    1
    MO1-lamb2 N/A 1
    MO2-lamb2 N/A 1
    MO3-lamb2 N/A 1
    DISEASE ASSOCIATED WITH lamb2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    nephrotic syndrome type 5 Alliance Nephrotic syndrome, type 5, with or without ocular abnormalities 614199
    Pierson syndrome Alliance Pierson syndrome 609049
    DISEASE ASSOCIATED WITH lamb2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process basement membrane assembly (more)
    Cellular Component laminin complex (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lamb2-201 (1)    Ensembl 5462
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lamb2 No data available
    MARKER RELATIONSHIPS
    lamb2 Contained in: [BAC] DKEY-32E6 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001243045 (1) 5465 nt
    Genomic GenBank:AL953864 (1) 249608 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B7ZDA6 (1) 1782 aa
    Sequence Information (all 19)
    ORTHOLOGY for lamb2 ( Chr: 23 )
    CITATIONS (30)