ZFIN ID: ZDB-GENE-081028-48
Gene Name: T, brachyury homolog b
Gene Symbol: tb
Previous Names: bra (1), brachyury (1), no tail b, ntlb, si:ch211-130h14.5
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Martin et al., 2008
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
  margin, mesoderm, notochord, tail bud (all 5) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31902 Point Mutation Unknown Unknown ENU
sa42127 Point Mutation Unknown Unknown ENU
Targeting reagents: MO1-tb (1), MO2-tb (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tb HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Sacral agenesis with vertebral anomalies 615709
{Neural tube defects, susceptibility to} 182940
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001699 (1)
  • InterPro:IPR002070 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR018186 (1)
  • PROSITE:PS01264 (1)
  • PROSITE:PS01283 (1)
  • PROSITE:PS50252 (1)
  • Pfam:PF00907 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tb-001 (1) 1583
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tbContained in: [BAC] CH211-130H14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001343597 (1) 2283bp
    Genomic GenBank:CR854838 (1) 154065bp
    Select Tool
    Polypeptide UniProtKB:X1WGE3 (1) 424aa
    Sequence Information (all 8)
    OTHER tb GENE PAGES
  • Gene:100004296 (1)
  • VEGA:OTTDARG00000029381 (1)
  • Ensembl(GRCz10):ENSDARG00000039806 (1)
  • ORTHOLOGY for tb (Chr: 13)
    Species Symbol Chromosome Accession # Evidence
    Human T 6
  • Gene:6862
  • OMIM:601397
  • HGNC:11515
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse T 17
  • MGI:98472
  • Gene:20997
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (21)