Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-081028-48
Gene Name: T, brachyury homolog b
Gene Symbol: tb
Previous Names: bra (1), brachyury (1), no tail b, ntlb, si:ch211-130h14.5
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from Martin et al., 2008
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Pharyngula:Prim-5 (24.0h-30.0h)
  margin, mesoderm, notochord, tail bud (all 5) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-tb (1), MO2-tb (1)
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Sacral agenesis with vertebral anomalies 615709
{Neural tube defects, susceptibility to} 182940
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of transcription, DNA-templated (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001699 (1)
  • InterPro:IPR002070 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR018186 (1)
  • PROSITE:PS01264 (1)
  • PROSITE:PS01283 (1)
  • PROSITE:PS50252 (1)
  • Pfam:PF00907 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ntlb-001 (1) 1275
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM tb No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    tb Contained in: [BAC] CH211-130H14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    Genomic GenBank:CR854838 (1) 154065 bp
    Select Tool
    Polypeptide UniProtKB:X1WGE3 (1) 426 aa
    Sequence Information (all 3)
    OTHER tb GENE PAGES
  • VEGA:OTTDARG00000029381 (1)
  • Ensembl(Zv9):ENSDARG00000039806 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish tb 13  
    Human T 6 (6q27)
  • OMIM:601397
  • Gene:6862
  • Mouse T 17 ( 4.92 cM)
  • MGI:98472
  • Gene:20997
  • Orthology Details
    CITATIONS (15)