ZFIN ID: ZDB-GENE-081027-2
Gene Name: microtubule-associated protein tau b
Gene Symbol: maptb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization and neuron projection development. Predicted to localize to neuron projection. Is expressed in nervous system; shield; spinal cord neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau).
Genome Resources: Alliance (1),  Gene:567833 (1),  Ensembl(GRCz11):ENSDARG00000087616 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH maptb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
frontotemporal dementia Alliance Dementia, frontotemporal, with or without parkinsonism 600274
late onset Parkinson's disease Alliance {Parkinson disease, susceptibility to} 168600
Pick's disease Alliance Pick disease 172700
progressive supranuclear palsy Alliance Supranuclear palsy, progressive 601104
Supranuclear palsy, progressive atypical 260540
DISEASE ASSOCIATED WITH maptb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process microtubule cytoskeleton organization (more)
Cellular Component cytoplasm (more)
Molecular Function microtubule binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA maptb-202 (1)    Ensembl 746
maptb-203 (1)    Ensembl 1266
maptb-204 (1)    Ensembl 719
maptb-205 (1)    Ensembl 800
maptb-206 (1)    Ensembl 4792
maptb-207 (1)    Ensembl 804
ncRNA maptb-006 (1) 1383
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM maptb No data available
MARKER RELATIONSHIPS
maptb Contained in: [BAC] CH73-176F10 (1), CH211-239N21 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_005171597 (1) 2521 nt
Genomic GenBank:BX649538 (1) 147441 nt
Select Tool
Polypeptide UniProtKB:E7F9D4 (1) 778 aa
Sequence Information (all 35)
ORTHOLOGY for maptb ( Chr: 3 )
CITATIONS (22)