ZFIN ID: ZDB-GENE-081027-1
Gene Name: microtubule-associated protein tau a
Gene Symbol: mapta    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have microtubule binding activity. Predicted to localize to cytoplasm and microtubule. Is expressed in central nervous system; chordo neural hinge; hypochord; and retinal ganglion cell. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau).
Genome Resources: Alliance (1),  Gene:100000342 (1),  Ensembl(GRCz11):ENSDARG00000089314 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22009 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41948 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mapta HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    frontotemporal dementia Alliance Dementia, frontotemporal, with or without parkinsonism 600274
    late onset Parkinson's disease Alliance {Parkinson disease, susceptibility to} 168600
    Pick's disease Alliance Pick disease 172700
    progressive supranuclear palsy Alliance Supranuclear palsy, progressive 601104
    Supranuclear palsy, progressive atypical 260540
    DISEASE ASSOCIATED WITH mapta VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasm (more)
    Molecular Function microtubule binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mapta-201 (1)    Ensembl 2151
    mapta-202 (1)    Ensembl 524
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mapta No data available
    MARKER RELATIONSHIPS
    mapta Contained in: [BAC] CH211-255P10 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021480214 (1)
    Genomic GenBank:AL935197 (1) 193113 nt
    Select Tool
    Polypeptide UniProtKB:E7FH04 (1) 406 aa
    Sequence Information (all 9)
    ORTHOLOGY for mapta ( Chr: 12 )
    CITATIONS (19)