ZFIN ID: ZDB-GENE-081022-110
Gene Name: cyclin-dependent kinase-like 5
Gene Symbol: cdkl5    Nomenclature History

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Previous Name: zgc:194395

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Exhibits cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in positive regulation of axon extension; protein phosphorylation; and regulation of dendrite development. Localizes to cytoplasm and nucleus. Is expressed in several structures, including eye; fin; gonad; heart; and muscle. Human ortholog(s) of this gene implicated in Rett syndrome; early infantile epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Orthologous to human CDKL5 (cyclin dependent kinase like 5).
Genome Resources: Alliance (1),  Gene:559341 (1),  Ensembl(GRCz11):ENSDARG00000015240 (2)
GENE EXPRESSION
All Expression Data: Fig. 6 from Katayama et al., 2016
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16950 Point Mutation Unknown Splice Site ENU
sa21938 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24892 Point Mutation Unknown Splice Site ENU
    sa35110 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35111 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cdkl5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 2 Alliance Epileptic encephalopathy, early infantile, 2 300672
    DISEASE ASSOCIATED WITH cdkl5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function cyclin-dependent protein serine/threonine kinase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdkl5-201 (1)    Ensembl 3936
    cdkl5-202 (1)    Ensembl 3479
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdkl5 No data available
    MARKER RELATIONSHIPS
    cdkl5 Contained in: [BAC] DKEY-163F14 (1) (order this)
    cdkl5 Encodes: [cDNA] MGC:194395 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001145768 (1) 3427 nt
    Genomic GenBank:CR790368 (1) 160194 nt
    Select Tool
    Polypeptide UniProtKB:B9X2H6 (1) 1080 aa
    Sequence Information (all 23)
    ORTHOLOGY for cdkl5 ( Chr: 11 )
    CITATIONS (20)