Gene

cdkl5

ID
ZDB-GENE-081022-110
Name
cyclin-dependent kinase-like 5
Symbol
cdkl5 Nomenclature History
Previous Names
  • zgc:194395
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Exhibits cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in positive regulation of axon extension; protein phosphorylation; and regulation of dendrite development. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Rett syndrome; early infantile epileptic encephalopathy 2; intellectual disability; and visual epilepsy. Is expressed in several structures, including eye; fin; gonad; heart; and muscle. Orthologous to human CDKL5 (cyclin dependent kinase like 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Katayama et al., 2016
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdkl5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 2 Alliance Developmental and epileptic encephalopathy 2 300672
Associated With cdkl5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:B9X2H6 1080
UniProtKB:B9X2H5 1039
UniProtKB:B3DI12 1039
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations