Gene

mbnl3

ID

ZDB-GENE-081002-3

Name

muscleblind-like splicing regulator 3

Symbol

mbnl3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including gill; heart; integument; nervous system; and pleuroperitoneal region. Used to study myotonic disease. Orthologous to human MBNL3 (muscleblind like splicing regulator 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hinman et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mbnl3 Human Ortholog

No data available

Associated With mbnl3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
myotonic disease	mbnl3^b1362/b1362	standard conditions	Hinman et al., 2021
myotonic disease	mbnl3^b1361/b1361	standard conditions	Hinman et al., 2021
myotonic disease	mbnl3^b1363/b1363	standard conditions	Hinman et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000571	Zinc finger, CCCH-type
Domain	IPR041367	E3 ligase, CCCH-type zinc finger
Domain	IPR054429	Muscleblind-like, CCCH zinc finger

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3AGP9	InterPro	393
UniProtKB:A9UH09	InterPro	381
UniProtKB:A0A8M9QP72	InterPro	356
UniProtKB:A0A8M9QGG7	InterPro	357
UniProtKB:A9UH12	InterPro	388
UniProtKB:F1R687	InterPro	355
UniProtKB:A0A8M9PZA3	InterPro	345
UniProtKB:F1REM0	InterPro	340

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mbnl3-201 (1) Ensembl	Ensembl	1,134 nt	Select Tool ZFIN BLAST
mRNA	mbnl3-202 (1) Ensembl	Ensembl	2,076 nt	Select Tool ZFIN BLAST
mRNA	mbnl3-203 (1) Ensembl	Ensembl	1,376 nt	Select Tool ZFIN BLAST
mRNA	mbnl3-204 (1) Ensembl	Ensembl	1,232 nt	Select Tool ZFIN BLAST
mRNA	mbnl3-206 (1) Ensembl	Ensembl	2,061 nt	Select Tool ZFIN BLAST
mRNA	mbnl3-207 (1) Ensembl	Ensembl	8,955 nt	Select Tool ZFIN BLAST
ncRNA	mbnl3-001 (1) Ensembl	Ensembl	1,664 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations