ZFIN ID: ZDB-GENE-080930-1
Gene Name: slow myosin heavy chain 3
Gene Symbol: smyhc3    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Is expressed in cephalic musculature; levator arcus palatini; superficial lateralis; and supracarinalis. Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7).
Genome Resources: Alliance (1),  Gene:100001337 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-smyhc
1
CRISPR2-smyhc
1
MO1-smyhc N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH smyhc3 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH smyhc3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Cellular Component myosin complex (more)
Molecular Function actin binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR002928 Myosin tail
Domain IPR004009 Myosin, N-terminal, SH3-like
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM smyhc3 No data available
MARKER RELATIONSHIPS
smyhc3 Contained in: [BAC] CH211-24N20 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001136523 (1) 5985 bp
Genomic GenBank:CU929259 (1) 195306 bp
Select Tool
Polypeptide UniProtKB:A0A2R8Q9I2 (1) 1952 aa
Sequence Information (all 16)
ORTHOLOGY for smyhc3 ( Chr: 24 )
CITATIONS (15)