ZFIN ID: ZDB-GENE-080929-1
Gene Name: alsin Rho guanine nucleotide exchange factor ALS2 b
Gene Symbol: als2b    Nomenclature History

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Previous Name: wu:fi21b09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have guanyl-nucleotide exchange factor activity. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2).
Genome Resources: Alliance (1),  Gene:100318899 (1),  Ensembl(GRCz11):ENSDARG00000076924 (2)
GENE EXPRESSION
All Expression Data: Fig. 6 from Gros-Louis et al., 2008
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: Expression Atlas (1)
DISEASE ASSOCIATED WITH als2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 2 Alliance Amyotrophic lateral sclerosis 2, juvenile 205100
Primary lateral sclerosis, juvenile 606353
Spastic paralysis, infantile onset ascending 607225
DISEASE ASSOCIATED WITH als2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Molecular Function guanyl-nucleotide exchange factor activity (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA als2b-202 (1)    Ensembl 7054
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM als2b No data available
MARKER RELATIONSHIPS
als2b Contained in: [BAC] CH73-272H16 (1), CH211-106F9, DKEY-203E20 (order this)
[Fosmid] CH1073-239F2 (1)
als2b Encodes: [EST] fi21b09
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_002662296 (1)
Genomic GenBank:BX927225 (1) 161068 nt
Select Tool
Polypeptide UniProtKB:F8W4K3 (1) 1681 aa
Sequence Information (all 22)
ORTHOLOGY for als2b ( Chr: 6 )
CITATIONS (23)