Gene

als2b

ID
ZDB-GENE-080929-1
Name
alsin Rho guanine nucleotide exchange factor ALS2 b
Symbol
als2b Nomenclature History
Previous Names
  • wu:fi21b09
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have guanyl-nucleotide exchange factor activity. Is expressed in head; muscle; retinal inner nuclear layer; and retinal outer nuclear layer. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 2. Orthologous to human ALS2 (alsin Rho guanine nucleotide exchange factor ALS2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With als2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 2 Alliance Amyotrophic lateral sclerosis 2, juvenile 205100
Primary lateral sclerosis, juvenile 606353
Spastic paralysis, infantile onset ascending 607225
Associated With als2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000219 Dbl homology (DH) domain
Domain IPR003123 VPS9 domain
Homologous_superfamily IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR037191 VPS9 domain superfamily
Repeat IPR000408 Regulator of chromosome condensation, RCC1
Repeat IPR003409 MORN motif
Domain Details Per Protein
Protein Length Dbl homology (DH) domain Dbl homology (DH) domain superfamily MORN motif PH-like domain superfamily Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II Regulator of chromosome condensation, RCC1 VPS9 domain VPS9 domain superfamily
UniProtKB:F1QIZ1 1607
UniProtKB:F8W4K3 1681
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations