Community Action Needed: Please respond to the NIH RFI
Gene

pbrm1

ID
ZDB-GENE-080926-4
Name
polybromo 1
Symbol
pbrm1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable DNA binding activity and chromatin binding activity. Predicted to act upstream of or within chromatin remodeling. Predicted to be located in nucleus. Predicted to be part of RSC-type complex. Is expressed in somite. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Armant et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pbrm1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
nonpapillary renal cell carcinoma Alliance ?Renal cell carcinoma, clear cell 144700
Associated With pbrm1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR001025 Bromo adjacent homology (BAH) domain
Domain IPR001487 Bromodomain
Domain IPR009071 High mobility group box domain
Domain IPR037968 Protein polybromo-1, Bromodomain 5
Family IPR037382 Remodelling complex subunit Rsc/polybromo
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Homologous_superfamily IPR043151 Bromo adjacent homology (BAH) domain superfamily
Domain Details Per Protein
Protein Length Bromo adjacent homology (BAH) domain Bromo adjacent homology (BAH) domain superfamily Bromodomain Bromodomain, conserved site Bromodomain-like superfamily High mobility group box domain High mobility group box domain superfamily Protein polybromo-1, Bromodomain 5 Remodelling complex subunit Rsc/polybromo
UniProtKB:E7F8D8 1627
UniProtKB:A0A0R4IQI8 1604
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations