ZFIN ID: ZDB-GENE-080917-49
Gene Name: WNK lysine deficient protein kinase 1a
Gene Symbol: wnk1a
Previous Name: im:7165255
Location: Chr: 25   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7165255]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  central nervous system, head, neural tube, notochord (all 7) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-wnk1a (1), MO2-wnk1a (1)

Allele Type Mutagen Suppliers
sa16044 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16394 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 3 figures from Lai et al., 2014
    Observed in: angiogenesis, cranial vasculature angiogenesis, cranial vasculature, dorsal longitudinal anastomotic vessel (all 6) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Neuropathy, hereditary sensory and autonomic, type II 201300
    Pseudohypoaldosteronism, type IIC 614492
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component cellular_component (more)
    Molecular Function ATP binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR024678 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF12202 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA wnk1a-001 (1) 8103
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wnk1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    wnk1a Contained in: [BAC] CH211-249B21 (1) (order this)
    wnk1a Encodes: [EST] IMAGE:7165255 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009298027 (1) 7496 bp
    Genomic GenBank:CR354611 (1) 81016 bp
    Select Tool
    Polypeptide UniProtKB:E7F2F9 (1) 1606 aa
    Sequence Clusters UniGene:156842 (1)
    Sequence Information (all 9)
    OTHER wnk1a GENE PAGES
  • Gene:100318736 (1)
  • VEGA:OTTDARG00000039406 (1)
  • Ensembl(Zv9):ENSDARG00000078992 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish wnk1a 25  
    Human WNK1 12 (12p13.3)
  • OMIM:605232
  • Gene:65125
  • Mouse Wnk1 6 ( 56.86 cM)
  • MGI:2442092
  • Gene:232341
  • Orthology Details
    CITATIONS (12)