Gene

wnk1a

ID
ZDB-GENE-080917-49
Name
WNK lysine deficient protein kinase 1a
Symbol
wnk1a Nomenclature History
Previous Names
  • im:7165255
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Involved in angiogenesis. Predicted to localize to cytosol. Is expressed in central nervous system; head; neural tube; notochord; and trunk. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Lai et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wnk1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 2A Alliance Neuropathy, hereditary sensory and autonomic, type II 201300
Pseudohypoaldosteronism, type IIC 614492
Associated With wnk1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase OSR1/WNK, CCT domain
UniProtKB:E7F2F9 1634
UniProtKB:X1WG08 1606
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations