ZFIN ID: ZDB-GENE-080917-49
Gene Name: WNK lysine deficient protein kinase 1a
Gene Symbol: wnk1a
Previous Name: im:7165255
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7165255]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  central nervous system, head, neural tube, notochord (all 7) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
sa16044 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16394 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-wnk1a (1), MO2-wnk1a (1)
    PHENOTYPE
    Data: 3 figures from Lai et al., 2014
    Observed in: angiogenesis, cranial vasculature angiogenesis, cranial vasculature, dorsal longitudinal anastomotic vessel (all 6) expand
    DISEASE ASSOCIATED WITH wnk1a HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hereditary sensory neuropathy Neuropathy, hereditary sensory and autonomic, type II 201300
    Pseudohypoaldosteronism, type IIC 614492
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component cytosol (more)
    Molecular Function ATP binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR002290 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR024678 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF12202 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA wnk1a-001 (1) 8103
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wnk1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    wnk1aContained in: [BAC] CH211-249B21 (1) (order this)
    wnk1aEncodes: [EST] IMAGE:7165255 (1) (order this)
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009298027 (1) 7496bp
    Genomic GenBank:CR354611 (1) 81016bp
    Select Tool
    Polypeptide UniProtKB:E7F2F9 (1) 1634aa
    Sequence Clusters UniGene:156842 (1)
    Sequence Information (all 10)
    OTHER wnk1a GENE PAGES 
  • Gene:100318736 (1)
  • VEGA:OTTDARG00000039406 (1)
  • Ensembl(GRCz10):ENSDARG00000078992 (1)
  • ORTHOLOGY for wnk1a (Chr: 25) 
    Species Symbol Chromosome Accession # Evidence
    Human WNK1 12
  • Gene:65125
  • OMIM:605232
  • HGNC:14540
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Wnk1 6
  • MGI:2442092
  • Gene:232341
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (12)