ZFIN ID: ZDB-GENE-080813-1
Gene Name: doublesex and mab-3 related transcription factor 2b
Gene Symbol: dmrt2b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in determination of left/right symmetry; muscle fiber development; and somitogenesis. Predicted to localize to the nucleus. Is expressed in digestive system; muscle; ovary; and somite. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2).
Genome Resources: Alliance (1),  Gene:558970 (1),  Ensembl(GRCz11):ENSDARG00000070013 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
imm005 Insertion Unknown Unknown TALEN
ioz21 Small Deletion Unknown Frameshift, Premature Stop CRISPR
sa31524 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dmrt2b 1
    MO1-dmrt2b N/A 1
    MO2-dmrt2b N/A 1
    MO3-dmrt2b N/A 1
    TALEN1-dmrt2b 1
    DISEASE ASSOCIATED WITH dmrt2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH dmrt2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001275 DM DNA-binding domain
    Family IPR026607 DMRT/protein doublesex/protein male abnormal 3
    Homologous_superfamily IPR036407 DM DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dmrt2b-201 (1)    Ensembl 1435
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dmrt2b No data available
    MARKER RELATIONSHIPS
    dmrt2b Contained in: [BAC] DKEY-15L7 (1) (order this), DKEY-52N11 (1) (order this)
    dmrt2b Encodes: [cDNA] MGC:195252 (1), MGC:195257 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001079976 (1) 1095 bp
    Genomic GenBank:BX293997 233655 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QDA7 (1) 364 aa
    Sequence Information (all 19)
    ORTHOLOGY for dmrt2b ( Chr: 6 )
    CITATIONS (25)