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ZIRC
ZFIN ID: ZDB-GENE-080725-1
Gene Name: SRY-box transcription factor 18
Gene Symbol: sox18    Nomenclature History

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Previous Name: si:ch211-235f6.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in artery development; lymphangiogenesis; and vasculogenesis. Predicted to localize to the nuclear transcription factor complex. Is expressed in several structures, including angioblastic mesenchymal cell; cardiovascular system; immature eye; intermediate cell mass of mesoderm; and mesoderm. Orthologous to human SOX18 (SRY-box transcription factor 18).
Genome Resources: Alliance (1),  Gene:797246 (1),  Ensembl(GRCz11):ENSDARG00000058598 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu10320 Insertion Unknown Unknown TALEN
sa12315 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sox18 N/A 6
    MO2-sox18 N/A 1
    MO3-sox18 N/A 1
    MO4-sox18 N/A 1
    MO5-sox18 N/A 8
    MO6-sox18 N/A 1
    MO7-sox18 N/A 2
    TALEN1-sox18 1
    DISEASE ASSOCIATED WITH sox18 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypotrichosis-lymphedema-telangiectasia syndrome Alliance Hypotrichosis-lymphedema-telangiectasia syndrome 607823
    hypotrichosis-lymphedema-telangiectasia-renal defect syndrome Alliance Hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 137940
    DISEASE ASSOCIATED WITH sox18 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process artery development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sox18-201 (1)    Ensembl 1530
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sox18 No data available
    MARKER RELATIONSHIPS
    sox18 Contained in: [BAC] CH211-235F6 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_017353772 (1)
    Genomic GenBank:CR457456 (1) 146468 bp
    Select Tool
    Polypeptide UniProtKB:E7F9I2 (1) 431 aa
    Sequence Clusters UniGene:88332 (1)
    Sequence Information (all 9)
    ORTHOLOGY for sox18 ( Chr: 23 )
    CITATIONS (47)