Gene

npm1b

ID
ZDB-GENE-080723-7
Name
nucleophosmin 1b
Symbol
npm1b Nomenclature History
Previous Names
  • npm4
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have chromatin binding activity and histone binding activity. Involved in hemopoiesis and regulation of apoptotic process. Predicted to localize to cytoplasm; nucleolus; and nucleoplasm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including eye; fin bud; hematopoietic cell; hematopoietic stem cell; and somite. Orthologous to human NPM1 (nucleophosmin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Bolli et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Bolli et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With npm1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
Associated With npm1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR024057 Nucleoplasmin core domain
Domain IPR032569 Nucleophosmin, C-terminal
Family IPR004301 Nucleoplasmin family
Homologous_superfamily IPR036824 Nucleoplasmin core domain superfamily
Domain Details Per Protein
Protein Length Nucleophosmin, C-terminal Nucleoplasmin core domain Nucleoplasmin core domain superfamily Nucleoplasmin family
UniProtKB:A0A2R8PZA4 298
UniProtKB:Q566X7 307
UniProtKB:Q0V948 306
UniProtKB:F1RD77 329
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Synteny with Gac npm4. ZDB-PUB-090706-7
Citations