ZFIN ID: ZDB-GENE-080723-11
Gene Name: zgc:193725
Gene Symbol: zgc:193725    Nomenclature History

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Previous Name: zgc:193713

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cholesterol efflux and intracellular cholesterol transport. Human ortholog(s) of this gene implicated in Niemann-Pick disease and Niemann-Pick disease type C2. Orthologous to human NPC2 (NPC intracellular cholesterol transporter 2).
Genome Resources: Alliance (1),  Gene:565099 (1),  Ensembl(GRCz11):ENSDARG00000096979 (1)

Nomenclature Note: This gene is characterized by full length cDNAs isolated as part of the Zebrafish Gene Collection (ZGC). When more is known about the gene, the current nomenclature will be replaced with more traditional zebrafish gene nomenclature. The prefix `zgc:' indicates that this gene is represented by cDNAs generated by the ZGC project.

GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23159 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH zgc:193725 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH zgc:193725 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular cholesterol transport (more)
    Molecular Function cholesterol binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003172 MD-2-related lipid-recognition domain
    Homologous_superfamily IPR014756 Immunoglobulin E-set
    Domain IPR033916 Npc2 like, ML domain
    Family IPR039670 Sterol transport protein NPC2-like
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA npc2 (1 of many)-201 (1)    Ensembl 516
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM zgc:193725 No data available
    MARKER RELATIONSHIPS
    zgc:193725 Contained in: [BAC] CH73-307J11 (1)
    zgc:193725 Encodes: [cDNA] MGC:193713 (1), MGC:193725 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128719 (1) 516 bp
    Genomic GenBank:CU929282 (1) 26423 bp
    Select Tool
    Polypeptide UniProtKB:B3DFW4 (1) 149 aa
    Sequence Information (all 13)
    ORTHOLOGY for zgc:193725 ( Chr: 17 )
    CITATIONS (12)