ZFIN ID: ZDB-GENE-080721-13
Gene Name: mitogen-activated protein kinase kinase 4b
Gene Symbol: map2k4b    Nomenclature History

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Previous Names: mkk4b (1), zgc:194486

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have JUN kinase kinase activity and protein serine/threonine kinase activity. Involved in convergent extension involved in gastrulation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in ovarian serous carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4).
Genome Resources: Alliance (1),  Gene:568951 (1),  Ensembl(GRCz11):ENSDARG00000077177 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Seo et al., 2010
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-map2k4b N/A 1
MO2-map2k4b N/A 1
DISEASE ASSOCIATED WITH map2k4b HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH map2k4b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process convergent extension involved in gastrulation (more)
Molecular Function ATP binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA map2k4b-201 (1)    Ensembl 1578
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM map2k4b No data available
MARKER RELATIONSHIPS
map2k4b Contained in: [Fosmid] ZFOS-2336A10
map2k4b Encodes: [cDNA] MGC:194486 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001089421 (1) 1377 nt
Genomic GenBank:FP017228 (1) 39049 nt
Select Tool
Polypeptide UniProtKB:A4UU31 (1) 417 aa
Sequence Information (all 21)
ORTHOLOGY for map2k4b ( Chr: 12 )
CITATIONS (18)