ZFIN ID: ZDB-GENE-080718-6
Gene Name: adducin 3 (gamma) b
Gene Symbol: add3b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Predicted to be involved in actin filament bundle assembly and barbed-end actin filament capping. Predicted to localize to cytoskeleton; plasma membrane raft; and postsynaptic density. Is expressed in intestine. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Orthologous to human ADD3 (adducin 3).
Genome Resources: Alliance (1),  Gene:553243 (1),  Ensembl(GRCz11):ENSDARG00000056250 (1)
GENE EXPRESSION
All Expression Data: Fig. 1 from Tang et al., 2016
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10508 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23045 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28836 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH add3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cerebral palsy, spastic quadriplegic, 3 617008
    DISEASE ASSOCIATED WITH add3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin filament bundle assembly (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA add3b-201 (1)    Ensembl 2432
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM add3b No data available
    MARKER RELATIONSHIPS
    add3b Contained in: [BAC] CH211-207N2 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001202527 (1) 2432 nt
    Genomic GenBank:BX005375 (1) 214178 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1QW07 (1) 722 aa
    Sequence Information (all 21)
    ORTHOLOGY for add3b ( Chr: 17 )
    CITATIONS (17)