ZFIN ID: ZDB-GENE-080718-4
Gene Name: adducin 2 (beta)
Gene Symbol: add2    Nomenclature History

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Previous Name: si:dkey-202n14.5 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Predicted to be involved in actin filament bundle assembly and barbed-end actin filament capping. Predicted to localize to cytoskeleton; plasma membrane raft; and postsynaptic density. Is expressed in head. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2).
Genome Resources: Alliance (1),  Gene:570147 (1),  Ensembl(GRCz11):ENSDARG00000074581 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Tang et al., 2016
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH add2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH add2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process actin filament bundle assembly (more)
Cellular Component cytoskeleton (more)
Molecular Function actin filament binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA add2-202 (1)    Ensembl 6262
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM add2 No data available
MARKER RELATIONSHIPS
add2 Contained in: [BAC] CH73-367H4 (1), DKEY-202N14 (1) (order this)
[Fosmid] CH1073-416J2 (1)
add2 Has Artifact: [EST] fk54d07
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001365434 (1)
Genomic GenBank:BX322550 (1) 184426 nt
Select Tool
Polypeptide UniProtKB:F1QTE3 (1) 669 aa
Sequence Information (all 30)
ORTHOLOGY for add2 ( Chr: 5 )
CITATIONS (25)