Gene

zeb2b

ID
ZDB-GENE-080717-1
Name
zinc finger E-box binding homeobox 2b
Symbol
zeb2b Nomenclature History
Previous Names
  • sip1b (1)
  • Smad-interacting protein-1b (1)
  • zfhx1b (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including convergent extension; mesenchymal cell differentiation; and regionalization. Predicted to be located in nucleus. Is expressed in several structures, including digestive system; nervous system; presumptive mesoderm; tail bud; and vagal neural crest. Human ortholog(s) of this gene implicated in Hirschsprung's disease and Mowat-Wilson syndrome. Orthologous to human ZEB2 (zinc finger E-box binding homeobox 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zeb2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mowat-Wilson syndrome Alliance Mowat-Wilson syndrome 235730
Associated With zeb2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Domain IPR008598 Drought induced 19 protein type, zinc-binding domain
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Drought induced 19 protein type, zinc-binding domain Homeobox domain Homeobox-like domain superfamily Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:A0A2R8QDL5 1191
UniProtKB:F1R6J7 1219
UniProtKB:A0A0R4IWE5 1170
UniProtKB:B0LVF0 1219
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations