ZFIN ID: ZDB-GENE-080616-2
Gene Name: myosin light chain kinase 2
Gene Symbol: mylk2    Nomenclature History

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Previous Names: skeletal muscle MLCK (1), skMLCK (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have myosin light chain kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in heart. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 1. Orthologous to human MYLK2 (myosin light chain kinase 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000031698 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014409Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24378 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mylk2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypertrophic cardiomyopathy 1 Alliance Cardiomyopathy, hypertrophic, 1, digenic 192600
    DISEASE ASSOCIATED WITH mylk2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Molecular Function ATP binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mylk2-202 (1)    Ensembl 3823
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mylk2 No data available
    MARKER RELATIONSHIPS
    mylk2 Contained in: [BAC] DKEY-126G1 (1) (order this), DKEY-197C14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:AB267909 (1) 4840 nt
    Genomic GenBank:BX927210 (1) 175627 nt
    Select Tool
    Polypeptide UniProtKB:F1QAR7 (1) 777 aa
    Sequence Information (all 5)
    ORTHOLOGY for mylk2 ( Chr: 23 )
    CITATIONS (20)