Gene
setd1a
- ID
- ZDB-GENE-080521-4
- Name
- SET domain containing 1A, histone lysine methyltransferase
- Symbol
- setd1a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity and histone methyltransferase activity (H3-K4 specific). Predicted to localize to Set1C/COMPASS complex. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| early-onset epilepsy 2 | Alliance | Epilepsy, early-onset, 2, with or without developmental delay | 618832 |
| neurodevelopmental disorder with speech impairment and dysmorphic facies | Alliance | Neurodevelopmental disorder with speech impairment and dysmorphic facies | 619056 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR024657 | COMPASS complex Set1 subunit, N-SET domain |
| Domain | IPR034467 | Set1A, RNA recognition motif |
| Domain | IPR037841 | Histone-lysine N-methyltransferase SETD1A/B-like, SET domain |
| Family | IPR044570 | Histone-lysine N-methyltransferase Set1-like |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | COMPASS complex Set1 subunit, N-SET domain | Histone-lysine N-methyltransferase Set1-like | Histone-lysine N-methyltransferase SETD1A/B-like, SET domain | Nucleotide-binding alpha-beta plait domain superfamily | Post-SET domain | RNA-binding domain superfamily | RNA recognition motif domain | Set1A, RNA recognition motif | SET domain | SET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PSI4
|
2252 | ||||||||||
|
UniProtKB:A0A8M1QQT7
|
2253 | ||||||||||
|
UniProtKB:E9QGQ0
|
2253 | ||||||||||
|
UniProtKB:A0A8M2BBI9
|
2252 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
setd1a-201
(1)
|
Ensembl | 6,762 nt | ||
| mRNA |
setd1a-202
(1)
|
Ensembl | 8,708 nt |
Interactions and Pathways
No data available
Plasmids
No data available