Gene

setd1a

ID

ZDB-GENE-080521-4

Name

SET domain containing 1A, histone lysine methyltransferase

Symbol

setd1a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable RNA binding activity and histone methyltransferase activity (H3-K4 specific). Predicted to act upstream of or within chromatin organization and methylation. Predicted to be part of Set1C/COMPASS complex. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setd1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Epilepsy, early-onset, with or without developmental delay	618832
		Neurodevelopmental disorder with speech impairment and dysmorphic facies	619056

Associated With setd1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR001214	SET domain
Domain	IPR003616	Post-SET domain
Domain	IPR024657	COMPASS complex Set1 subunit, N-SET domain
Domain	IPR034467	Set1A, RNA recognition motif
Family	IPR037841	Histone-lysine N-methyltransferase SETD1A
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	COMPASS complex Set1 subunit, N-SET domain	Histone-lysine N-methyltransferase SETD1A	Nucleotide-binding alpha-beta plait domain superfamily	Post-SET domain	RNA-binding domain superfamily	RNA recognition motif domain	Set1A, RNA recognition motif	SET domain
UniProtKB:Q071D7 InterPro	406
UniProtKB:E9QGQ0 InterPro	2253

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	setd1a-202 (1) Ensembl	8708 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations