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Gene

setd1a

ID
ZDB-GENE-080521-4
Name
SET domain containing 1A, histone lysine methyltransferase
Symbol
setd1a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable RNA binding activity and histone methyltransferase activity (H3-K4 specific). Predicted to act upstream of or within chromatin organization and methylation. Predicted to be part of Set1C/COMPASS complex. Orthologous to human SETD1A (SET domain containing 1A, histone lysine methyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With setd1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epilepsy, early-onset, with or without developmental delay 618832
Neurodevelopmental disorder with speech impairment and dysmorphic facies 619056
Associated With setd1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000504 RNA recognition motif domain
Domain IPR001214 SET domain
Domain IPR003616 Post-SET domain
Domain IPR024657 COMPASS complex Set1 subunit, N-SET domain
Domain IPR034467 Set1A, RNA recognition motif
Family IPR037841 Histone-lysine N-methyltransferase SETD1A
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
Domain Details Per Protein
Protein Length COMPASS complex Set1 subunit, N-SET domain Histone-lysine N-methyltransferase SETD1A Nucleotide-binding alpha-beta plait domain superfamily Post-SET domain RNA-binding domain superfamily RNA recognition motif domain Set1A, RNA recognition motif SET domain
UniProtKB:Q071D7 406
UniProtKB:E9QGQ0 2253
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations