ZFIN ID: ZDB-GENE-080521-3
Gene Name: lysine (K)-specific methyltransferase 2A
Gene Symbol: kmt2a    Nomenclature History

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Previous Names: mll, im:7148357

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have histone methyltransferase activity (H3-K4 specific). Involved in glial cell development; nucleate erythrocyte development; and paraxial mesoderm development. Predicted to localize to histone methyltransferase complex. Is expressed in several structures, including blastoderm; blastodisc; intermediate cell mass of mesoderm; nervous system; and renal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A).
Genome Resources: Alliance (1),  Gene:557048 (1),  Ensembl(GRCz11):ENSDARG00000004537 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb506 Small Deletion Exon 1 Unknown TALEN
ihb507 Small Deletion Exon 5 Unknown CRISPR
sa137 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa2815 Point Mutation Unknown Premature Stop ENU
    sa10905 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19111 Point Mutation Unknown Premature Stop ENU
    sa22638 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24984 Point Mutation Unknown Premature Stop ENU
    sa35881 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42541 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kmt2a 1
    MO1-kmt2a N/A 2
    MO2-kmt2a N/A 1
    MO3-kmt2a N/A 2
    MO4-kmt2a N/A 1
    MO5-kmt2a N/A 1
    TALEN1-kmt2a 1
    DISEASE ASSOCIATED WITH kmt2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Wiedemann-Steiner syndrome 605130
    DISEASE ASSOCIATED WITH kmt2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process paraxial mesoderm development (more)
    Cellular Component histone methyltransferase complex (more)
    Molecular Function DNA binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kmt2a-202 (1)    Ensembl 13967
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kmt2a No data available
    MARKER RELATIONSHIPS
    kmt2a Contained in: [BAC] CH211-195H14
    kmt2a Encodes: [EST] IMAGE:7148357 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110279 (1) 12703 nt
    Genomic GenBank:CR847979 (1) 117096 nt
    Select Tool
    Polypeptide UniProtKB:C0LNQ6 (1) 4219 aa
    Sequence Information (all 36)
    ORTHOLOGY for kmt2a ( Chr: 15 )
    CITATIONS (37)