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Gene

kmt2a

ID
ZDB-GENE-080521-3
Name
lysine (K)-specific methyltransferase 2A
Symbol
kmt2a Nomenclature History
Previous Names
  • mll
  • im:7148357
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to enable histone methyltransferase activity (H3-K4 specific). Acts upstream of or within glial cell development; nucleate erythrocyte development; and paraxial mesoderm development. Predicted to be located in nucleus. Predicted to be part of histone methyltransferase complex. Is expressed in several structures, including blastoderm; blastodisc; intermediate cell mass of mesoderm; nervous system; and renal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia; cervical cancer; mixed phenotype acute leukemia; and non-Hodgkin lymphoma. Orthologous to human KMT2A (lysine methyltransferase 2A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kmt2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Wiedemann-Steiner syndrome 605130
Associated With kmt2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001214 SET domain
Domain IPR001487 Bromodomain
Domain IPR001965 Zinc finger, PHD-type
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR002857 Zinc finger, CXXC-type
Domain IPR003616 Post-SET domain
Domain IPR003888 FY-rich, N-terminal
Domain IPR003889 FY-rich, C-terminal
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR034732 Extended PHD (ePHD) domain
Domain IPR041958 KMT2A, ePHD domain
Domain IPR042023 KMT2A, PHD domain 1
Domain IPR042025 KMT2A, PHD domain 2
Domain IPR044133 KMT2A, PHD domain 3
Family IPR016569 Methyltransferase, trithorax
Family IPR037927 Histone-lysine N-methyltransferase 2A
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Domain Details Per Protein
Protein Length Bromodomain Bromodomain-like superfamily Extended PHD (ePHD) domain FY-rich, C-terminal FY-rich, N-terminal Histone-lysine N-methyltransferase 2A KMT2A, ePHD domain KMT2A, PHD domain 1 KMT2A, PHD domain 2 KMT2A, PHD domain 3 Methyltransferase, trithorax Post-SET domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain SET domain Zinc finger, CXXC-type Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, RING/FYVE/PHD-type
UniProtKB:F8W578 4218
UniProtKB:A5XBQ8 96
UniProtKB:I2BJN8 255
UniProtKB:A4L9R9 136
UniProtKB:C0LNQ7 148
UniProtKB:A4L9S0 4137
UniProtKB:Q071D5 750
UniProtKB:C0LNQ6 4219
UniProtKB:Q071D6 1154
UniProtKB:A8VKP8 4218
UniProtKB:F1QL52 4219
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations