ZFIN ID: ZDB-GENE-080521-1
Gene Name: lysine (K)-specific methyltransferase 2Bb
Gene Symbol: kmt2bb    Nomenclature History

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Previous Name: mll4b

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have histone methyltransferase activity (H3-K4 specific). Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Predicted to localize to the histone methyltransferase complex. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; dystonia; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B).
Genome Resources: Alliance (1),  Gene:566825 (1),  Ensembl(GRCz11):ENSDARG00000060697 (2)
GENE EXPRESSION
All Expression Data: Fig. S6 from Sun et al., 2008
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Blastula:Sphere (4.0h-4.33h)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH kmt2bb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dystonia 28, childhood-onset 617284
DISEASE ASSOCIATED WITH kmt2bb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process histone H3-K4 methylation (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001214 SET domain
Domain IPR001965 Zinc finger, PHD-type
Domain IPR002857 Zinc finger, CXXC-type
Domain IPR003616 Post-SET domain
Domain IPR003888 FY-rich, N-terminal
Domain IPR003889 FY-rich, C-terminal
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR034732 Extended PHD (ePHD) domain
Homologous_superfamily IPR036427 Bromodomain-like superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA kmt2bb-201 (1)    Ensembl 15341
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM kmt2bb No data available
MARKER RELATIONSHIPS
kmt2bb Contained in: [BAC] CH211-51D2, CH211-137J23 (1), DKEY-88F20 (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_002664671 (1) 11784 bp
Genomic GenBank:CT027748 (1) 166105 bp
Select Tool
Polypeptide UniProtKB:F8W580 (1) 3772 aa
Sequence Information (all 13)
ORTHOLOGY for kmt2bb ( Chr: 15 )
CITATIONS (22)