ZFIN ID: ZDB-GENE-080519-2
Gene Name: nuclear receptor binding SET domain protein 1b
Gene Symbol: nsd1b
Location: Chr: 21 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: Fig. S6 from Sun et al., 2008
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Blastula:Sphere (4.0h-4.33h)
  whole organism
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
sa24006 Point Mutation ENU
Targeting reagents: MO1-nsd1b (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH nsd1b HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
acute myeloid leukemia Leukemia, acute myeloid 601626
Beckwith-Wiedemann syndrome Beckwith-Wiedemann syndrome 130650
Sotos syndrome Sotos syndrome 1 117550
GENE ONTOLOGY
Ontology GO Term
Biological Process methylation (more)
Cellular Component nucleus (more)
Molecular Function histone-lysine N-methyltransferase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000313 (1)
  • InterPro:IPR001214 (1)
  • InterPro:IPR001965 (1)
  • InterPro:IPR003616 (1)
  • InterPro:IPR006560 (1)
  • InterPro:IPR011011 (1)
  • InterPro:IPR013083 (1)
  • InterPro:IPR019786 (1)
  • InterPro:IPR019787 (1)
  • PROSITE:PS01359 (1)
  • PROSITE:PS50016 (1)
  • PROSITE:PS50280 (1)
  • PROSITE:PS50812 (1)
  • PROSITE:PS50868 (1)
  • PROSITE:PS51215 (1)
  • Pfam:PF00855 (1)
  • Pfam:PF00856 (1)
  • EC:2.1.1.43 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nsd1b-001 (1) 5720
    ncRNA nsd1b-002 (1) 464
    mRNA nsd1b-003 (1) 906
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nsd1b No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    nsd1bContained in: [BAC] DKEY-13F9 (1) (order this), DKEY-106J22 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005173883 (1) 6403bp
    Genomic GenBank:BX842703 (1) 208780bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q9U9 (1) 1873aa
    Sequence Clusters UniGene:119918 (1)
    Sequence Information (all 27)
    OTHER nsd1b GENE PAGES
  • Gene:564592 (1)
  • VEGA:OTTDARG00000031645 (1)
  • Ensembl(GRCz10):ENSDARG00000060705 (1)
  • ORTHOLOGY for nsd1b (Chr: 21)
    Species Symbol Chromosome Accession # Evidence
    Human NSD1 5
  • Gene:64324
  • OMIM:606681
  • HGNC:14234
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Nsd1 13
  • MGI:1276545
  • Gene:18193
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (15)