ZFIN ID: ZDB-GENE-080514-1
Gene Name: solute carrier family 18 member 2
Gene Symbol: slc18a2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: vmat2 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have serotonin:sodium symporter activity. Involved in swimming behavior. Predicted to localize to synaptic vesicle membrane and terminal bouton. Is expressed in brain and neurons. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in Parkinson's disease and type 1 diabetes mellitus. Orthologous to human SLC18A2 (solute carrier family 18 member A2).
Genome Resources: Alliance (1),  Gene:553304 (1),  Ensembl(GRCz11):ENSDARG00000015110 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013072Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6475 Point Mutation Unknown Premature Stop ENU
    sa12325 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36403 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36404 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sus100 Small Deletion Exon 3 Frameshift CRISPR
    sus101 Insertion Exon 3 Frameshift CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slc18a2 1
    MO1-slc18a2 N/A 1
    DISEASE ASSOCIATED WITH slc18a2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Parkinsonism-dystonia, infantile, 2 618049
    DISEASE ASSOCIATED WITH slc18a2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    anxiety disorder slc18a2sus100/+ standard conditions Wang et al., 2016
    slc18a2sus101/+ standard conditions Wang et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process swimming behavior (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane transporter activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc18a2-201 (1)    Ensembl 1762
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc18a2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(slc18a2:GFP) slc18a2 GFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    slc18a2 Contained in: [BAC] CH211-243K10 (1), DKEY-7N14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001256225 (1) 1771 nt
    Genomic GenBank:CR384057 (1) 154493 nt
    Select Tool
    Polypeptide UniProtKB:F1QVV1 (1) 562 aa
    Sequence Information (all 12)
    ORTHOLOGY for slc18a2 ( Chr: 17 )
    CITATIONS (38)