ZFIN ID: ZDB-GENE-080513-1
Gene Name: mohawk homeobox a
Gene Symbol: mkxa    Nomenclature History

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Previous Name: irxl1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits DNA binding activity. Involved in embryonic viscerocranium morphogenesis; myoblast differentiation; and negative regulation of transcription, DNA-templated. Predicted to localize to the nucleus. Is expressed in several structures, including nervous system; neurocranial trabecula; notochord; pharyngeal arch; and pleuroperitoneal region. Orthologous to human MKX (mohawk homeobox).
Genome Resources: Alliance (1),  Gene:799136 (1),  Ensembl(GRCz11):ENSDARG00000075450 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018120Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11810 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mkxa
    2
    MO1-mkxa N/A 2
    MO2-mkxa N/A 1
    DISEASE ASSOCIATED WITH mkxa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mkxa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic viscerocranium morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR001356 Homeobox domain
    Domain IPR008422 Homeobox KN domain
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mkxa-201 (1)    Ensembl 2947
    ncRNA mkxa-002 (1)    Ensembl 1934
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mkxa No data available
    MARKER RELATIONSHIPS
    mkxa Contained in: [BAC] CH211-87G12 (1)
    mkxa Encodes: [cDNA] MGC:198385 (1), MGC:198387 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001098733 (1) 2945 nt
    Genomic GenBank:BX927312 (1) 124706 nt
    Select Tool
    Polypeptide UniProtKB:A5YC44 (1) 349 aa
    Sequence Information (all 20)
    ORTHOLOGY for mkxa ( Chr: 12 )
    CITATIONS (26)