ZFIN Gene: cadm2b

ZFIN ID: ZDB-GENE-080506-3

ZFIN ID: ZDB-GENE-080506-3

Gene Name:

cell adhesion molecule 2b

Gene Symbol:

cadm2b Nomenclature History

Previous Name:

Gene Type:

protein_coding_gene

Location:

Chr: 15 Mapping Details/Browsers

Description:

Involved in glial cell development and retina development in camera-type eye. Predicted to localize to integral component of membrane. Is expressed in eye; immature eye; and nervous system. Human ortholog(s) of this gene implicated in astrocytoma; autism spectrum disorder; obesity; psoriasis; and type 2 diabetes mellitus. Orthologous to human CADM2 (cell adhesion molecule 2).

Genome Resources:

Alliance (1), Gene:571698 (1), Ensembl(GRCz11):ENSDARG00000062633 (1)

GENE EXPRESSION
All Expression Data:	4 figures from Pietri et al., 2008
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
	anterior lateral line ganglion caudal octavolateralis nucleus caudal tuberculum central caudal thalamic nucleus central nervous system central nucleus inferior lobe central nucleus torus semicircularis corpus cerebelli deep white zone descending octaval nucleus dorsal telencephalon dorsal thalamus epiphysis facial lobe glomerular layer granular eminence habenula horizontal cell hypothalamus immature eye inferior lobe lens magnocellular preoptic nucleus magnocellular superficial pretectal nucleus medial longitudinal fasciculus medial octavolateralis nucleus medulla oblongata nucleus isthmi nucleus lateralis valvulae olfactory bulb olfactory epithelium optic tectum periventricular nucleus pretectal periventricular nucleus pretectum retina retinal bipolar neuron retinal ganglion cell layer retinal inner nuclear layer retinal outer nuclear layer retinal rod cell rostral octaval nucleus rostral parvocellular preoptic nucleus rostral preglomerular nucleus rostral thalamic nucleus spinal cord spinal cord interneuron suprachiasmatic nucleus tegmentum torus semicircularis vagal lobe valvula cerebelli ventral telencephalon ventral thalamus ventrolateral nucleus ventromedial thalamic nucleus

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa22591	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-cadm2b		1
CRISPR2-cadm2b		1

PHENOTYPE

Data:	2 figures from Charlton-Perkins et al., 2019
Observed in:	Muller cell cell body Muller cell glial cell projection Muller cell retinal inner plexiform layer retinal outer plexiform layer

DISEASE ASSOCIATED WITH cadm2b HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH cadm2b VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	glial cell development (more)
Cellular Component	integral component of membrane (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS No data available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM cadm2b No data available

MARKER RELATIONSHIPS

cadm2b Contained in:

[BAC] CH211-276A12

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001113555 (1)	1206 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR589941 (1)	203085 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:B0F6R2 (1)	401 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 23)

ORTHOLOGY for cadm2b ( Chr: 15 )

CITATIONS (15)

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