Gene
megf10
- ID
- ZDB-GENE-080506-1
- Name
- multiple EGF-like-domains 10
- Symbol
- megf10 Nomenclature History
- Previous Names
-
- fc33e05
- wu:fc33e05 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Involved in myofibril assembly. Predicted to localize to integral component of membrane and plasma membrane. Used to study myopathy. Human ortholog(s) of this gene implicated in early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10).
- Genome Resources
- Note
- None
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome | Alliance | Myopathy, areflexia, respiratory distress, and dysphagia, early-onset | 614399 |
early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome | Alliance | Myopathy, areflexia, respiratory distress, and dysphagia, early-onset, mild variant | 614399 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
myopathy | megf10sa13029/sa13029 | standard conditions | Saha et al., 2019 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | EGF-like, conserved site | EGF-like domain | EMI domain | Laminin EGF domain |
---|---|---|---|---|---|
UniProtKB:X1WG68
|
1074 | ||||
UniProtKB:A0A2R8QIB3
|
1142 | ||||
UniProtKB:E9QJQ6
|
1119 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
megf10-201
(1)
|
3544 nt | |
ncRNA |
megf10-002
(1)
|
797 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl