Gene

megf10

ID

ZDB-GENE-080506-1

Name

multiple EGF-like-domains 10

Symbol

megf10 Nomenclature History

Previous Names

fc33e05
wu:fc33e05 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Involved in myofibril assembly. Predicted to localize to integral component of membrane and plasma membrane. Used to study myopathy. Human ortholog(s) of this gene implicated in early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10).

Genome Resources

Note

None

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With megf10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome	Alliance	Myopathy, areflexia, respiratory distress, and dysphagia, early-onset	614399
early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome	Alliance	Myopathy, areflexia, respiratory distress, and dysphagia, early-onset, mild variant	614399

Associated With megf10 Via Experimental Models

Human Disease	Fish	Conditions	Citations
myopathy	megf10^{sa13029/sa13029}	standard conditions	Saha et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR002049	Laminin EGF domain
Domain	IPR011489	EMI domain

Domain Details Per Protein

Protein	Length	EGF-like, conserved site	EGF-like domain	EMI domain	Laminin EGF domain
UniProtKB:X1WG68 InterPro	1074
UniProtKB:A0A2R8QIB3 InterPro	1142
UniProtKB:E9QJQ6 InterPro	1119

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	megf10-201 (1) Ensembl	3544 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	megf10-002 (1) Ensembl	797 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations