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ZIRC
ZFIN ID: ZDB-GENE-080506-1
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Gene Name: multiple EGF-like-domains 10
Gene Symbol: megf10
Sequence Ontology ID : SO:0001217

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Previous Names: fc33e05, wu:fc33e05 (1)

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(Including Attributions)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in myofibril assembly. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in early-onset myopathy-areflexia-respiratory distress-dysphagia  ...
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6165 Point Mutation Unknown Premature Stop ENU
sa6166 Point Mutation Unknown Splice Site ENU
sa13029 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa21693 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa30934 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa34867 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa34868 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa34869 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa38788 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa41612 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 2 figures from Boyden et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH megf10 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome Myopathy, areflexia, respiratory distress, and dysphagia, early-onset 614399
    Myopathy, areflexia, respiratory distress, and dysphagia, early-onset, mild variant 614399
    DISEASE ASSOCIATED WITH megf10 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myofibril assembly (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000742 (1)
  • InterPro:IPR002049 (1)
  • InterPro:IPR011489 (1)
  • InterPro:IPR013032 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51041 (1)
  • Pfam:PF00053 (1)
  • Pfam:PF12661 (1)
    • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA megf10-002 (1) 797
    Select Tool
    mRNA megf10-201 (1) 3544
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM megf10 No data available
    MARKER RELATIONSHIPS
    megf10 Contained in: [BAC] DKEY-184A18 (1) (order this)
    megf10 Encodes: [EST] fc33e05
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001922489 (1) 4915 bp
    Select Tool
    Genomic GenBank:CR396586 (1) 225060 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QIB3 (1) 1142 aa
    Select Tool
    Sequence Clusters UniGene:137501 (1)
    Sequence Information (all 15)
    OTHER megf10 GENE PAGES
  • Alliance (1)
  • Gene:564571 (1)
  • VEGA:OTTDARG00000031113 (1)
  • Ensembl(GRCz11):ENSDARG00000017229 (2)
    • ORTHOLOGY for megf10 ( Chr: 10 )
    CITATIONS (21)