Gene

megf10

ID
ZDB-GENE-080506-1
Name
multiple EGF-like-domains 10
Symbol
megf10 Nomenclature History
Previous Names
  • fc33e05
  • wu:fc33e05 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Involved in myofibril assembly. Predicted to localize to integral component of membrane and plasma membrane. Used to study myopathy. Human ortholog(s) of this gene implicated in early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With megf10 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome Alliance Myopathy, areflexia, respiratory distress, and dysphagia, early-onset 614399
early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome Alliance Myopathy, areflexia, respiratory distress, and dysphagia, early-onset, mild variant 614399
Associated With megf10 Via Experimental Models
Human Disease Fish Conditions Citations
myopathy megf10sa13029/sa13029 standard conditions Saha et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Domain IPR000742 EGF-like domain
Domain IPR002049 Laminin EGF domain
Domain IPR011489 EMI domain
Domain Details Per Protein
Protein Length EGF-like, conserved site EGF-like domain EMI domain Laminin EGF domain
UniProtKB:X1WG68 1074
UniProtKB:A0A2R8QIB3 1142
UniProtKB:E9QJQ6 1119
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations