ZFIN ID: ZDB-GENE-080425-5
Gene Name: myosin XVIIIAa
Gene Symbol: myo18aa    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: myo18b (1), myo18l2

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in Golgi organization; cell-matrix adhesion; and striated muscle cell development. Predicted to localize to the myosin complex. Is expressed in somite border. Orthologous to human MYO18A (myosin XVIIIA).
Genome Resources: Alliance (1),  Gene:566880 (1),  Ensembl(GRCz11):ENSDARG00000075752 (2)
GENE EXPRESSION
All Expression Data: Fig. 1 from Cao et al., 2014
Wild-type Stages, Structures: Cleavage:32-cell (1.75h-2.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12353 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13591 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14885 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16330 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21785 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34956 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34957 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34958 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41712 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sdu12 Small Deletion Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-myo18aa N/A 2
    TALEN1-myo18aa
    1
    TALEN2-myo18aa 1
    DISEASE ASSOCIATED WITH myo18aa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH myo18aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell-matrix adhesion (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001478 PDZ domain
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002928 Myosin tail
    Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Family IPR031244 Unconventional myosin-XVIIIa
    Homologous_superfamily IPR036034 PDZ superfamily
    Domain IPR036064 Class XVIII myosin, motor domain
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myo18aa-202 (1)    Ensembl 8585
    ncRNA ottdart00000059962 (1) 539
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo18aa No data available
    MARKER RELATIONSHIPS
    myo18aa Contained in: [BAC] DKEY-106A24 (1) (order this), DKEY-263L2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_690164 (1) 8572 bp
    Genomic GenBank:BX323076 (1) 156437 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4J7R2 (1) 2454 aa
    Sequence Information (all 31)
    ORTHOLOGY for myo18aa ( Chr: 10 )
    CITATIONS (22)