ZFIN ID: ZDB-GENE-080425-3
Gene Name: forkhead box O1 b
Gene Symbol: foxo1b    Nomenclature History

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Previous Name: foxo1a.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in lymph vessel development. Predicted to localize to cytoplasm and nucleus. Is expressed in head; olfactory epithelium; and pericardial region. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1).
Genome Resources: Alliance (1),  Gene:567969 (1),  Ensembl(GRCz11):ENSDARG00000061549 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34936 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-foxo1b N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH foxo1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    alveolar rhabdomyosarcoma Alliance Rhabdomyosarcoma, alveolar 268220
    DISEASE ASSOCIATED WITH foxo1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lymph vessel development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxo1b-201 (1)    Ensembl 2022
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxo1b No data available
    MARKER RELATIONSHIPS
    foxo1b Contained in: [BAC] CH211-244D10
    foxo1b Encodes: [cDNA] MGC:194494 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001082857 (1) 1890 nt
    Genomic GenBank:AL953846 (1) 153939 nt
    Select Tool
    Polypeptide UniProtKB:A3RK75 (1) 629 aa
    Sequence Information (all 12)
    ORTHOLOGY for foxo1b ( Chr: 10 )
    CITATIONS (30)