ZFIN ID: ZDB-GENE-080425-2
Gene Name: myosin XVAa
Gene Symbol: myo15aa    Nomenclature History

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Previous Names: myo15a (1), myo15l1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin binding activity; and motor activity. Predicted to be involved in sensory perception of sound. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Is expressed in midbrain hindbrain boundary neural plate; presumptive rhombomere 3; and presumptive rhombomere 5. Orthologous to human MYO15A (myosin XVA).
Genome Resources: Alliance (1),  Gene:560592 (1),  Ensembl(GRCz11):ENSDARG00000075292 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6043 Point Mutation Unknown Premature Stop ENU
sa6909 Point Mutation Unknown Splice Site ENU
sa6910 Point Mutation Unknown Splice Site ENU
sa11241 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13847 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15876 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20095 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40133 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40134 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44570 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myo15aa
    1
    CRISPR2-myo15aa
    3
    CRISPR3-myo15aa
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH myo15aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 3 Alliance Deafness, autosomal recessive 3 600316
    DISEASE ASSOCIATED WITH myo15aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sensory perception of sound (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR000299 FERM domain
    Domain IPR000857 MyTH4 domain
    Domain IPR001452 SH3 domain
    Domain IPR001609 Myosin head, motor domain
    Domain IPR019748 FERM central domain
    Domain IPR019749 Band 4.1 domain
    Domain IPR041795 Myosin-XV, FERM domain C-lobe
    Family IPR035487 Unconventional myosin-XV
    Homologous_superfamily IPR011993 PH-like domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR035963 FERM superfamily, second domain
    Homologous_superfamily IPR036028 SH3-like domain superfamily
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    Homologous_superfamily IPR038185 MyTH4 domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myo15aa-201 (1)    Ensembl 12857
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo15aa No data available
    MARKER RELATIONSHIPS
    myo15aa Contained in: [BAC] DKEY-19E10 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021474708 (1)
    Genomic GenBank:BX649547 (1) 237569 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F8W622 (1) 4115 aa
    Sequence Information (all 8)
    ORTHOLOGY for myo15aa ( Chr: 3 )
    CITATIONS (21)