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ZIRC
ZFIN ID: ZDB-GENE-080424-5
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Gene Name: myosin IXAa
Gene Symbol: myo9aa    Nomenclature History

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Previous Names: myo9a1 (1), myo9al1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; GTPase activator activity; and actin binding activity. Involved in axon extension and swimming behavior. Predicted to localize to several cellular components, including the cell junction; growth cone; and myosin complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).
Genome Resources: Alliance (1),  Gene:100006612 (1),  Ensembl(GRCz11):ENSDARG00000076729 (2)
GENE EXPRESSION
All Expression Data: Fig. S2 from O'Connor et al., 2016
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026180Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la026181Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la029378Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa7606 Point Mutation Unknown Missense ENU
    sa11190 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa12066 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa12095 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa15001 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa21098 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa21099 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa25371 Point Mutation Unknown Premature Stop ENU
    sa27066 Point Mutation Unknown Premature Stop ENU
    sa31607 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa34203 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa38645 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myo9aa
    		1
    CRISPR2-myo9aa
    		1
    MO1-myo9aa N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH myo9aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Myasthenic syndrome, congenital, 24, presynaptic 618198
    DISEASE ASSOCIATED WITH myo9aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon development (more)
    Cellular Component cell junction (more)
    Molecular Function actin binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000048 (1)
  • InterPro:IPR000159 (1)
  • InterPro:IPR000198 (1)
  • InterPro:IPR001609 (1)
  • InterPro:IPR002219 (1)
  • InterPro:IPR008936 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR028558 (1)
  • InterPro:IPR029071 (1)
  • InterPro:IPR036023 (1)
  • InterPro:IPR036961 (1)
  • PROSITE:PS00479 (1)
  • PROSITE:PS50081 (1)
  • PROSITE:PS50096 (1)
  • PROSITE:PS50200 (1)
  • PROSITE:PS50238 (1)
  • PROSITE:PS51456 (1)
  • Pfam:PF00063 (1)
  • Pfam:PF00612 (1)
  • Pfam:PF00620 (1)
  • Pfam:PF00788 (1)
    • TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo9aa No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009303504 (1)
    Select Tool
    Genomic GenBank:CR388017 (1) 111978 bp
    Select Tool
    Polypeptide UniProtKB:E7EZG2 (1) 2522 aa
    Select Tool
    Sequence Clusters UniGene:85760 (1)
    Sequence Information (all 38)
    ORTHOLOGY for myo9aa ( Chr: 7 )
    CITATIONS (23)