Gene
myo9aa
- ID
- ZDB-GENE-080424-5
- Name
- myosin IXAa
- Symbol
- myo9aa Nomenclature History
- Previous Names
-
- myo9a1 (1)
- myo9al1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have several functions, including ATP binding activity; GTPase activator activity; and actin binding activity. Involved in axon extension; neuromuscular junction development, skeletal muscle fiber; and swimming behavior. Predicted to localize to several cellular components, including growth cone; myosin complex; and synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).
- Genome Resources
- Note
- None
- All Expression Data
- 1 figure from O'Connor et al., 2016
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Connor et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Myasthenic syndrome, congenital, 24, presynaptic | 618198 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR000159 | Ras-associating (RA) domain |
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001609 | Myosin head, motor domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR036023 | Class IX myosin, motor domain |
| Family | IPR028558 | Unconventional myosin-IXa |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | Class IX myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain | P-loop containing nucleoside triphosphate hydrolase | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras-associating (RA) domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | Ubiquitin-like domain superfamily | Unconventional myosin-IXa |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7EZG2
|
2522 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl