Gene
myo9aa
- ID
- ZDB-GENE-080424-5
- Name
- myosin IXAa
- Symbol
- myo9aa Nomenclature History
- Previous Names
-
- myo9a1 (1)
- myo9al1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within axon extension; neuromuscular junction development, skeletal muscle fiber; and swimming behavior. Predicted to be located in several cellular components, including cytoplasm; growth cone; and synapse. Predicted to be part of myosin complex. Predicted to be active in actin filament and axonal growth cone. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from O'Connor et al., 2016
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Connor et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Myasthenic syndrome, congenital, 24, presynaptic | 618198 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR000159 | Ras-associating domain |
| Domain | IPR000198 | Rho GTPase-activating protein domain |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR028558 | Unconventional myosin-IXa, Ras-associating domain |
| Domain | IPR036023 | Class IX myosin, motor domain |
| Family | IPR046987 | Unconventional class IX myosin |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Class IX myosin, motor domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Ras-associating domain | Rho GTPase-activating protein domain | Rho GTPase activation protein | Ubiquitin-like domain superfamily | Unconventional class IX myosin | Unconventional myosin-IXa, Ras-associating domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13ABL8 | InterPro | 2522 | |||||||||||||
| UniProtKB:A0AB32TRU3 | InterPro | 2584 | |||||||||||||
| UniProtKB:A0AB32TTG9 | InterPro | 2547 | |||||||||||||
| UniProtKB:A0AB32TTH4 | InterPro | 2572 | |||||||||||||
| UniProtKB:A0AB32TUF8 | InterPro | 2546 | |||||||||||||
| UniProtKB:A0AB32TW79 | InterPro | 2509 | |||||||||||||
| UniProtKB:A0AB32TXV9 | InterPro | 2566 | |||||||||||||
| UniProtKB:A0AB32TXZ1 | InterPro | 2540 | |||||||||||||
| UniProtKB:E7EZG2 | InterPro | 2522 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo9aa-201
(1)
|
Ensembl | 7,569 nt |
Interactions and Pathways
No data available
Plasmids
No data available