Gene

myo9aa

ID
ZDB-GENE-080424-5
Name
myosin IXAa
Symbol
myo9aa Nomenclature History
Previous Names
  • myo9a1 (1)
  • myo9al1
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have several functions, including ATP binding activity; GTPase activator activity; and actin binding activity. Involved in axon extension; neuromuscular junction development, skeletal muscle fiber; and swimming behavior. Predicted to localize to several cellular components, including growth cone; myosin complex; and synapse. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome. Orthologous to human MYO9A (myosin IXA).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from O'Connor et al., 2016
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from O'Connor et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myo9aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Myasthenic syndrome, congenital, 24, presynaptic 618198
Associated With myo9aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR000159 Ras-associating (RA) domain
Domain IPR000198 Rho GTPase-activating protein domain
Domain IPR001609 Myosin head, motor domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR036023 Class IX myosin, motor domain
Family IPR028558 Unconventional myosin-IXa
Homologous_superfamily IPR008936 Rho GTPase activation protein
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Class IX myosin, motor domain IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain P-loop containing nucleoside triphosphate hydrolase Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Ras-associating (RA) domain Rho GTPase-activating protein domain Rho GTPase activation protein Ubiquitin-like domain superfamily Unconventional myosin-IXa
UniProtKB:E7EZG2 2522
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations