Gene
grik2
- ID
- ZDB-GENE-080414-1
- Name
- glutamate receptor, ionotropic, kainate 2
- Symbol
- grik2 Nomenclature History
- Previous Names
-
- grik2l
- grik2alpha (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Human ortholog(s) of this gene implicated in Huntington's disease and autosomal recessive non-syndromic intellectual disability. Is expressed in Bergmann glial cell; cerebellum; granule cell; hindbrain; and optic tectum. Orthologous to human GRIK2 (glutamate ionotropic receptor kainate type subunit 2).
- Genome Resources
-
- Alliance (1)
- Gene:556013 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yan et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 6 | Alliance | Intellectual developmental disorder, autosomal recessive 6 | 611092 |
| Neurodevelopmental disorder with impaired language and ataxia and with or without seizures | 619580 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
| Family | IPR015683 | Ionotropic glutamate receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Domain Details Per Protein
| Protein | Length | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PDB6
|
870 | ||||||
|
UniProtKB:A0A8M9P836
|
908 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance