ZFIN ID: ZDB-GENE-080409-2
Gene Name: ATPase plasma membrane Ca2+ transporting 3b
Gene Symbol: atp2b3b    Nomenclature History

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Previous Name: pmca3b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have PDZ domain binding activity and calcium transmembrane transporter activity, phosphorylative mechanism. Predicted to be involved in regulation of cytosolic calcium ion concentration. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1 and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B3 (ATPase plasma membrane Ca2+ transporting 3).
Genome Resources: Alliance (1),  Gene:558525 (1),  Ensembl(GRCz11):ENSDARG00000023445 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Liao et al., 2007
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028496Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10773 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18149 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24299 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24300 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37671 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37672 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43953 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43954 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH atp2b3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    X-linked spinocerebellar ataxia 1 Alliance ?Spinocerebellar ataxia, X-linked 1 302500
    DISEASE ASSOCIATED WITH atp2b3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp2b3b-203 (1)    Ensembl 9347
    ncRNA atp2b3b-002 (1) 510
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp2b3b No data available
    MARKER RELATIONSHIPS
    atp2b3b Contained in: [BAC] DKEY-93L1 (1) (order this), DKEY-233H12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128242 (1) 4580 nt
    Genomic GenBank:CR352234 (1) 198117 nt
    Select Tool
    Polypeptide UniProtKB:A0A286Y8X6 (1) 1180 aa
    Sequence Information (all 21)
    ORTHOLOGY for atp2b3b ( Chr: 23 )
    CITATIONS (22)