Gene

tert

ID
ZDB-GENE-080405-1
Name
telomerase reverse transcriptase
Symbol
tert Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Enables telomerase activity. Acts upstream of or within several processes, including erythrocyte maturation; intestinal epithelial structure maintenance; and telomere maintenance via telomerase. Located in nucleus. Predicted to be part of telomerase catalytic core complex. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase reverse transcriptase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tert Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute myeloid leukemia Alliance {Leukemia, acute myeloid} 601626
autosomal dominant dyskeratosis congenita 2 Alliance Dyskeratosis congenita, autosomal dominant 2 613989
autosomal dominant dyskeratosis congenita 2 Alliance Dyskeratosis congenita, autosomal recessive 4 613989
Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 614742
{Melanoma, cutaneous malignant, 9} 615134
Associated With tert Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000477 Reverse transcriptase domain
Domain IPR021891 Telomerase ribonucleoprotein complex - RNA-binding domain
Family IPR003545 Telomerase reverse transcriptase
Homologous_superfamily IPR043502 DNA/RNA polymerase superfamily
Domain Details Per Protein
Protein Length DNA/RNA polymerase superfamily Reverse transcriptase domain Telomerase reverse transcriptase Telomerase ribonucleoprotein complex - RNA-binding domain
UniProtKB:B6ZLJ8 1098
UniProtKB:B3DIZ2 1098
UniProtKB:B4XPB6 1091
UniProtKB:F8W2L0 57
UniProtKB:F1QE52 1098
UniProtKB:F8W2Z1 160
UniProtKB:A2THE9 1098
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations