Gene

tert

ID

ZDB-GENE-080405-1

Name

telomerase reverse transcriptase

Symbol

tert Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Enables telomerase activity. Acts upstream of or within several processes, including erythrocyte maturation; intestinal epithelial structure maintenance; and telomere maintenance via telomerase. Located in nucleus. Predicted to be part of telomerase catalytic core complex. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase reverse transcriptase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tert Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	{Leukemia, acute myeloid}	601626
autosomal dominant dyskeratosis congenita 2	Alliance	Dyskeratosis congenita, autosomal dominant 2	613989
autosomal dominant dyskeratosis congenita 2	Alliance	Dyskeratosis congenita, autosomal recessive 4	613989
		Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1	614742
		{Melanoma, cutaneous malignant, 9}	615134

Associated With tert Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000477	Reverse transcriptase domain
Domain	IPR021891	Telomerase ribonucleoprotein complex - RNA-binding domain
Family	IPR003545	Telomerase reverse transcriptase
Homologous_superfamily	IPR043502	DNA/RNA polymerase superfamily

Domain Details Per Protein

Protein	Length	DNA/RNA polymerase superfamily	Reverse transcriptase domain	Telomerase reverse transcriptase	Telomerase ribonucleoprotein complex - RNA-binding domain
UniProtKB:B6ZLJ8 InterPro	1098
UniProtKB:B3DIZ2 InterPro	1098
UniProtKB:B4XPB6 InterPro	1091
UniProtKB:F8W2L0 InterPro	57
UniProtKB:F1QE52 InterPro	1098
UniProtKB:F8W2Z1 InterPro	160
UniProtKB:A2THE9 InterPro	1098

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tert-201 (1) Ensembl	3536 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tert-202 (1) Ensembl	689 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tert-203 (1) Ensembl	453 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tert-002 (1) Ensembl	798 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations