ZFIN Gene: tert

ZFIN ID: ZDB-GENE-080405-1

ZFIN ID: ZDB-GENE-080405-1

Gene Name:

telomerase reverse transcriptase

Gene Symbol:

tert Nomenclature History

Previous Name:

Gene Type:

protein_coding_gene

Location:

Chr: 19 Mapping Details/Browsers

Description:

Exhibits telomerase activity. Involved in several processes, including erythrocyte maturation; intestinal epithelial structure maintenance; and telomere maintenance via telomerase. Localizes to nucleus. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase reverse transcriptase).

Genome Resources:

Alliance (1), Gene:796551 (1), Ensembl(GRCz11):ENSDARG00000042637 (2)

GENE EXPRESSION
All Expression Data:	7 figures from 4 publications
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
	brain eye gill head kidney heart integument kidney liver muscle ovary photoreceptor outer segment layer retina retinal ganglion cell layer retinal inner nuclear layer retinal outer nuclear layer retinal outer plexiform layer whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
f9	Small Deletion	Unknown	Unknown	ZINC_FINGER_NUCLEASE
f10	Small Deletion	Unknown	Unknown	ZINC_FINGER_NUCLEASE
hu3430	Point Mutation	Exon 2	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
la020927Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa6541	Point Mutation	Unknown	Premature Stop	ENU
sa25076	Point Mutation	Unknown	Premature Stop	ENU

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-tert	N/A	2
MO2-tert	N/A	1

PHENOTYPE

Data:

27 figures from 6 publications

Observed in:

DISEASE ASSOCIATED WITH tert HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	{Leukemia, acute myeloid}	601626
autosomal dominant dyskeratosis congenita 2	Alliance	{Dyskeratosis congenita, autosomal dominant 2}	613989
		{Dyskeratosis congenita, autosomal recessive 4}	613989
		{Melanoma, cutaneous malignant, 9}	615134
		{Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1}	614742

DISEASE ASSOCIATED WITH tert VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	intestinal epithelial structure maintenance (more)
Cellular Component	nucleus (more)
Molecular Function	telomerase activity (more)

GO Terms (all 21)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	tert-201 (1)	3536	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tert-202 (1)	689	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tert-203 (1)	453	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tert-002 (1)	798	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM tert No data available

MARKER RELATIONSHIPS

tert Contained in:	[BAC] CH73-166J22 (1) [Fosmid] CH1073-199L10 (1)
tert Encodes:	[cDNA] MGC:194607 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001083866 (1)	3530 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU856173 (1)	124203 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A2THE9 (1)	1098 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 25)

ORTHOLOGY for tert ( Chr: 19 )

CITATIONS (57)

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