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ZIRC
ZFIN ID: ZDB-GENE-080405-1
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Gene Name: telomerase reverse transcriptase
Gene Symbol: tert    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Exhibits telomerase activity. Involved in several processes, including erythrocyte maturation; intestinal epithelial structure maintenance; and telomere maintenance via telomerase. Localizes to the nucleus. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human TERT (telomerase reverse transcriptase).
Genome Resources: Alliance (1),  Gene:796551 (1),  Ensembl(GRCz11):ENSDARG00000042637 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 4 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
f9 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
f10 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
hu3430 Point Mutation Exon 2 Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la020927Tg Transgenic Insertion Unknown Unknown DNA
    sa6541 Point Mutation Unknown Premature Stop ENU
    sa25076 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tert N/A 2
    MO2-tert N/A 1
    PHENOTYPE
    Data: 27 figures from 6 publications
    Observed in:
    DISEASE ASSOCIATED WITH tert HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance {Leukemia, acute myeloid} 601626
    autosomal dominant dyskeratosis congenita 2 Alliance {Dyskeratosis congenita, autosomal dominant 2} 613989
    {Dyskeratosis congenita, autosomal recessive 4} 613989
    {Melanoma, cutaneous malignant, 9} 615134
    {Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1} 614742
    DISEASE ASSOCIATED WITH tert VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intestinal epithelial structure maintenance (more)
    Cellular Component nucleus (more)
    Molecular Function telomerase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000477 (1)
  • InterPro:IPR003545 (1)
  • InterPro:IPR021891 (1)
  • PROSITE:PS50878 (1)
  • Pfam:PF00078 (1)
  • Pfam:PF12009 (1)
  • EC:2.7.7.49 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tert-201 (1)    Ensembl 3536
    Select Tool
    tert-202 (1)    Ensembl 689
    Select Tool
    tert-203 (1)    Ensembl 453
    Select Tool
    ncRNA tert-002 (1)    Ensembl 798
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tert No data available
    MARKER RELATIONSHIPS
    tert Contained in: [BAC] CH73-166J22 (1) (order this)
    [Fosmid] CH1073-199L10 (1) (order this)
    tert Encodes: [cDNA] MGC:194607 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001083866 (1) 3530 bp
    Select Tool
    Genomic GenBank:CU856173 (1) 124203 bp
    Select Tool
    Polypeptide UniProtKB:A2THE9 (1) 1098 aa
    Select Tool
    Sequence Clusters UniGene:87388 (1)
    Sequence Information (all 26)
    ORTHOLOGY for tert ( Chr: 19 )
    CITATIONS (54)