| ZFIN ID: ZDB-GENE-080403-16 |
| Gene Name: | E1A binding protein p300 a | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | ep300a Nomenclature History |
{{control.fieldName}} Edit
Attributions
|
||||||||||||
| Previous Names: | EP300b1 (1), EP300b2 (1), P300-A (1), gb:dq017643, im:7158255 | |||||||||||||
Add new Alias
Attributions for Alias: {{control.newAlias}}
Delete Alias:(Including Attributions) |
||||||||||||||
| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 12 Mapping Details/Browsers | |||||||||||||
| Description: | Exhibits histone acetyltransferase activity. Involved in embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to localize to histone acetyltransferase complex. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and liver. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:559273 (1), Ensembl(GRCz11):ENSDARG00000100666 (1) | |||||||||||||
| All Expression Data: | 9 figures from 3 publications |
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7158255] |
| 7 figures (7 images) from Thisse et al., 2008 [dq017643] | |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| a360 | Small Deletion | Unknown | Unknown | CRISPR | |
| la012135Tg | Transgenic Insertion | Unknown | Unknown | DNA | |
| la012136Tg | Transgenic Insertion | Unknown | Unknown | DNA |
|
| la018088Tg | Transgenic Insertion | Unknown | Unknown | DNA |
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| CRISPR1-ep300a |
|
1 |
| CRISPR2-ep300a |
|
1 |
| CRISPR3-ep300a | 1 | |
| CRISPR4-ep300a | 1 | |
| CRISPR5-ep300a | 1 | |
| CRISPR6-ep300a | 1 | |
| MO1-ep300a | N/A | 1 |
| MO2-ep300a | N/A | 1 |
| MO3-ep300a | N/A | 1 |
| MO4-ep300a | N/A | 1 |
PHENOTYPE
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Rubinstein-Taybi syndrome | Alliance | Rubinstein-Taybi syndrome 2 | 613684 |
| Menke-Hennekam syndrome 2 | 618333 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | embryonic cranial skeleton morphogenesis (more) |
| Cellular Component | histone acetyltransferase complex (more) |
| Molecular Function | histone acetyltransferase activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
ep300a-202
(1)
|
10239 |
Select Tool
|
| Browsers: NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM ep300a
No data available
MARKER RELATIONSHIPS
| ep300a Contained in: | [BAC] CH211-120D1 (1), CH211-167D24 |
| ep300a Encodes: | [EST] dq017643 (1), IMAGE:7158255 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:XM_009306693 (1) |
Select Tool
|
|
| Genomic | GenBank:CU914479 (1) | 160074 nt | |
| Polypeptide | UniProtKB:A0A0R4IUG1 (1) | 2679 aa |
Select Tool
|
ORTHOLOGY for ep300a (
Chr:
12
)
CITATIONS (29)