ZFIN ID: ZDB-GENE-080403-16
Gene Name: E1A binding protein p300 a
Gene Symbol: ep300a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: EP300b1 (1), EP300b2 (1), P300-A (1), gb:dq017643, im:7158255

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits histone acetyltransferase activity. Involved in embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to localize to histone acetyltransferase complex. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and liver. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300).
Genome Resources: Alliance (1),  Gene:559273 (1),  Ensembl(GRCz11):ENSDARG00000100666 (1)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7158255]
  7 figures (7 images) from Thisse et al., 2008 [dq017643]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a360 Small Deletion Unknown Unknown CRISPR
la012135Tg Transgenic Insertion Unknown Unknown DNA
la012136Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018088Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ep300a
    1
    CRISPR2-ep300a
    1
    CRISPR3-ep300a 1
    CRISPR4-ep300a 1
    CRISPR5-ep300a 1
    CRISPR6-ep300a 1
    MO1-ep300a N/A 1
    MO2-ep300a N/A 1
    MO3-ep300a N/A 1
    MO4-ep300a N/A 1
    DISEASE ASSOCIATED WITH ep300a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    Rubinstein-Taybi syndrome Alliance Rubinstein-Taybi syndrome 2 613684
    Menke-Hennekam syndrome 2 618333
    DISEASE ASSOCIATED WITH ep300a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic cranial skeleton morphogenesis (more)
    Cellular Component histone acetyltransferase complex (more)
    Molecular Function histone acetyltransferase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ep300a-202 (1)    Ensembl 10239
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ep300a No data available
    MARKER RELATIONSHIPS
    ep300a Contained in: [BAC] CH211-120D1 (1), CH211-167D24
    ep300a Encodes: [EST] dq017643 (1), IMAGE:7158255 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009306693 (1)
    Genomic GenBank:CU914479 (1) 160074 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IUG1 (1) 2679 aa
    Sequence Information (all 49)
    ORTHOLOGY for ep300a ( Chr: 12 )
    CITATIONS (29)