Gene
ep300a
- ID
- ZDB-GENE-080403-16
- Name
- E1A binding protein p300 a
- Symbol
- ep300a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables histone acetyltransferase activity. Acts upstream of or within embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and liver. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7158255 (1 image)
- dq017643 (7 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Rubinstein-Taybi syndrome | Alliance | Rubinstein-Taybi syndrome 2 | 613684 |
| Menke-Hennekam syndrome 2 | 618333 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Domain | IPR000197 | Zinc finger, TAZ-type |
| Domain | IPR000433 | Zinc finger, ZZ-type |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR003101 | Coactivator CBP, KIX domain |
| Domain | IPR010303 | CREB-binding protein/p300, atypical RING domain |
| Domain | IPR014744 | Nuclear receptor coactivator, CREB-bp-like, interlocking |
| Domain | IPR031162 | CBP/p300-type histone acetyltransferase domain |
| Family | IPR013178 | Histone acetyltransferase Rtt109/CBP |
| Homologous_superfamily | IPR009110 | Nuclear receptor coactivator, interlocking |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR035898 | TAZ domain superfamily |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR036529 | Coactivator CBP, KIX domain superfamily |
| Homologous_superfamily | IPR038547 | CBP/p300, atypical RING domain superfamily |
| Homologous_superfamily | IPR043145 | Zinc finger, ZZ-type superfamily |
Domain Details Per Protein
| Protein | Length | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | CBP/p300, atypical RING domain superfamily | CBP/p300-type histone acetyltransferase domain | Coactivator CBP, KIX domain | Coactivator CBP, KIX domain superfamily | CREB-binding protein/p300, atypical RING domain | Histone acetyltransferase Rtt109/CBP | Nuclear receptor coactivator, CREB-bp-like, interlocking | Nuclear receptor coactivator, interlocking | TAZ domain superfamily | Zinc finger, RING/FYVE/PHD-type | Zinc finger, TAZ-type | Zinc finger, ZZ-type | Zinc finger, ZZ-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1L663
|
186 | ||||||||||||||||
|
UniProtKB:A0A0R4IUG1
|
2679 | ||||||||||||||||
|
UniProtKB:A0A0R4IPF3
|
2671 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
ep300a-202
(1)
|
10239 nt |
Interactions and Pathways
No data available
Plasmids
No data available