Gene

ep300a

ID
ZDB-GENE-080403-16
Name
E1A binding protein p300 a
Symbol
ep300a Nomenclature History
Previous Names
  • EP300b1 (1)
  • EP300b2 (1)
  • P300-A (1)
  • gb:dq017643
  • im:7158255
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits histone acetyltransferase activity. Involved in embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to localize to histone acetyltransferase complex and transcription regulator complex. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and liver. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ep300a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Colorectal cancer, somatic 114500
Menke-Hennekam syndrome 2 618333
Rubinstein-Taybi syndrome 2 613684
Associated With ep300a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018359 Bromodomain, conserved site
Domain IPR000197 Zinc finger, TAZ-type
Domain IPR000433 Zinc finger, ZZ-type
Domain IPR001487 Bromodomain
Domain IPR003101 Coactivator CBP, KIX domain
Domain IPR010303 CREB-binding protein/p300, atypical RING domain
Domain IPR014744 Nuclear receptor coactivator, CREB-bp-like, interlocking
Domain IPR031162 CBP/p300-type histone acetyltransferase domain
Family IPR013178 Histone acetyltransferase Rtt109/CBP
Homologous_superfamily IPR009110 Nuclear receptor coactivator, interlocking
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR035898 TAZ domain superfamily
Homologous_superfamily IPR036427 Bromodomain-like superfamily
Homologous_superfamily IPR036529 Coactivator CBP, KIX domain superfamily
Homologous_superfamily IPR037073 Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily
Homologous_superfamily IPR038547 CBP/p300, atypical RING domain superfamily
Homologous_superfamily IPR043145 Zinc finger, ZZ-type superfamily
Domain Details Per Protein
Protein Length Bromodomain Bromodomain, conserved site Bromodomain-like superfamily CBP/p300, atypical RING domain superfamily CBP/p300-type histone acetyltransferase domain Coactivator CBP, KIX domain Coactivator CBP, KIX domain superfamily CREB-binding protein/p300, atypical RING domain Histone acetyltransferase Rtt109/CBP Nuclear receptor coactivator, CREB-bp-like, interlocking Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily Nuclear receptor coactivator, interlocking TAZ domain superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, TAZ-type Zinc finger, ZZ-type Zinc finger, ZZ-type superfamily
UniProtKB:A0A8M3B7G7 2673
UniProtKB:A0A8M3B4N4 2672
UniProtKB:A0A8M3BE74 2663
UniProtKB:A0A8M9PFF3 2672
UniProtKB:A0A8M9QMW4 2681
UniProtKB:A0A8M9PYD9 2681
UniProtKB:A0A8M3AYE1 2661
UniProtKB:A0A8M9PSB9 2663
UniProtKB:A0A8M9PYE4 2661
UniProtKB:A0A8M9PSB5 2681
UniProtKB:A0A8M9PTF6 1975
UniProtKB:A0A8M9Q4R2 2673
UniProtKB:A0A8M9Q0N1 1965
UniProtKB:A0A8M3BE71 2682
UniProtKB:A0A8M3AYD6 2680
UniProtKB:A0A8M9PFE9 2682
UniProtKB:A0A8M9PAU5 1956
UniProtKB:A0A8M9Q3W4 1966
UniProtKB:A0A8M9Q9D0 2680
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA ep300a-201 (1) Ensembl 8016 nt
mRNA ep300a-202 (1) Havana 10239 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations