ZFIN ID: ZDB-GENE-080403-15
Gene Name: E1A binding protein p300 b
Gene Symbol: ep300b    Nomenclature History

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Previous Names: EP300a (1), P300-B (1), fj84f01, gb:dq017642, wu:fj84f01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have histone acetyltransferase activity; transcription coactivator activity; and zinc ion binding activity. Involved in embryonic cranial skeleton morphogenesis; heart looping; and pectoral fin development. Predicted to localize to histone acetyltransferase complex. Is expressed in blastoderm; blastomere; brain; intestinal bulb; and ventricular zone. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; and congestive heart failure. Orthologous to human EP300 (E1A binding protein p300).
Genome Resources: Alliance (1),  Gene:565612 (1),  Ensembl(GRCz11):ENSDARG00000061108 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 2 publications
Directly Submitted Expression Data: 7 figures (8 images) from Thisse et al., 2008 [dq017642]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a361 Complex Unknown Unknown CRISPR
sa6888 Point Mutation Unknown Premature Stop ENU
sa6889 Point Mutation Unknown Splice Site ENU
sa20005 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26061 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31327 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31328 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33171 Point Mutation Unknown Premature Stop ENU
    sa33172 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa33173 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38388 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ep300b 1
    CRISPR2-ep300b 1
    CRISPR3-ep300b 1
    CRISPR4-ep300b 1
    MO1-ep300b N/A 1
    MO2-ep300b N/A 1
    MO3-ep300b N/A 1
    MO4-ep300b N/A 1
    DISEASE ASSOCIATED WITH ep300b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    Rubinstein-Taybi syndrome Alliance Rubinstein-Taybi syndrome 2 613684
    Menke-Hennekam syndrome 2 618333
    DISEASE ASSOCIATED WITH ep300b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic cranial skeleton morphogenesis (more)
    Cellular Component histone acetyltransferase complex (more)
    Molecular Function histone acetyltransferase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ep300b-202 (1)    Ensembl 10791
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ep300b No data available
    MARKER RELATIONSHIPS
    ep300b Contained in: [BAC] CH73-369F20, CH211-280J3, DKEY-271F3 (order this)
    ep300b Encodes: [EST] dq017642 (1), fj84f01
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009299407 (1)
    Genomic GenBank:AL954851 177221 nt
    Select Tool
    Polypeptide UniProtKB:X1WG57 (1) 2615 aa
    Sequence Information (all 33)
    ORTHOLOGY for ep300b ( Chr: 3 )
    CITATIONS (26)