Gene

il2rgb

ID
ZDB-GENE-080402-2
Name
interleukin 2 receptor, gamma b
Symbol
il2rgb Nomenclature History
Previous Names
  • il2rgc.b (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have cytokine receptor activity and interleukin-2 binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in brain; eye; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il2rgb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined T cell and B cell immunodeficiency Alliance Combined immunodeficiency, X-linked, moderate 312863
X-linked severe combined immunodeficiency Alliance Severe combined immunodeficiency, X-linked 300400
Associated With il2rgb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003531 Short hematopoietin receptor, family 1, conserved site
Domain IPR003961 Fibronectin type III
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Short hematopoietin receptor, family 1, conserved site
UniProtKB:A8WH91 385
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations