Gene

il2rgb

ID
ZDB-GENE-080402-2
Name
interleukin 2 receptor, gamma b
Symbol
il2rgb Nomenclature History
Previous Names
  • il2rgc.b (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have cytokine receptor activity and granulocyte colony-stimulating factor binding activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in brain; eye; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il2rgb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Combined immunodeficiency, X-linked, moderate 312863
Severe combined immunodeficiency, X-linked 300400
Associated With il2rgb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003531 Short hematopoietin receptor, family 1, conserved site
Domain IPR003961 Fibronectin type III
Domain IPR048651 Cytokine receptor-like factor 2-like, D1 domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Cytokine receptor-like factor 2-like, D1 domain Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Short hematopoietin receptor, family 1, conserved site
UniProtKB:A0A8M3AGM8 391
UniProtKB:A8WH91 385
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA il2rgb-201 (1) Havana 1864 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations