ZFIN ID: ZDB-GENE-080402-1
Gene Name: interleukin 2 receptor, gamma a
Gene Symbol: il2rga    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: il2rgc.a (1), si:dkey-18a10.4

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have cytokine receptor activity and interleukin-2 binding activity. Involved in lymphocyte differentiation. Predicted to localize to external side of plasma membrane and receptor complex. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and thymus. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).
Genome Resources: Alliance (1),  Gene:796604 (1),  Ensembl(GRCz11):ENSDARG00000068858 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fb104 Small Deletion Unknown Unknown TALEN
mdu1 Small Deletion Unknown Unknown TALEN
mdu2 Indel Unknown Unknown TALEN
mdu3 Small Deletion Unknown Unknown TALEN
mdu4 Small Deletion Unknown Unknown TALEN
sa14683 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31788 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45415 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-il2rga N/A 1
    MO2-il2rga N/A 1
    TALEN1-il2rga 2
    TALEN2-il2rga 2
    PHENOTYPE
    Data: 2 figures from Sertori et al., 2016
    Observed in:
    DISEASE ASSOCIATED WITH il2rga HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    combined T cell and B cell immunodeficiency Alliance Combined immunodeficiency, X-linked, moderate 312863
    X-linked severe combined immunodeficiency Alliance Severe combined immunodeficiency, X-linked 300400
    DISEASE ASSOCIATED WITH il2rga VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process lymphocyte differentiation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cytokine receptor activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA il2rga-201 (1)    Ensembl 1135
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM il2rga No data available
    MARKER RELATIONSHIPS
    il2rga Contained in: [BAC] DKEY-18A10 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001128271 (1) 1135 nt
    Genomic GenBank:CR759796 (1) 130961 nt
    Select Tool
    Polypeptide UniProtKB:A8WH93 (1) 362 aa
    Sequence Information (all 8)
    ORTHOLOGY for il2rga ( Chr: 10 )
    CITATIONS (21)