Gene

il2rga

ID
ZDB-GENE-080402-1
Name
interleukin 2 receptor, gamma a
Symbol
il2rga Nomenclature History
Previous Names
  • il2rgc.a (1)
  • si:dkey-18a10.4
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have cytokine receptor activity and interleukin-2 binding activity. Involved in lymphocyte differentiation. Predicted to localize to external side of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in X-linked severe combined immunodeficiency; combined T cell and B cell immunodeficiency; and severe combined immunodeficiency. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and thymus. Orthologous to human IL2RG (interleukin 2 receptor subunit gamma).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Sertori et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With il2rga Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-linked severe combined immunodeficiency Alliance Severe combined immunodeficiency, X-linked 300400
Combined immunodeficiency, X-linked, moderate 312863
Associated With il2rga Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR003531 Short hematopoietin receptor, family 1, conserved site
Domain IPR003961 Fibronectin type III
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Short hematopoietin receptor, family 1, conserved site
UniProtKB:A8WH93 362
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations