ZFIN ID: ZDB-GENE-080320-2
Gene Name: calcium channel, voltage-dependent, beta 4a subunit
Gene Symbol: cacnb4a
Previous Names: CAB4a (1), cacnb4.2 (1)
Location: Chr: 9   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
  atrium, blastoderm, brain, cerebellum (all 27) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-cacnb4a (1)
PHENOTYPE
Data: 2 figures from Ebert et al., 2008
Observed in: central nervous system, epiboly involved in gastrulation with mouth forming second, marginal blastomere, whole organism (all 5) expand
DISEASE ASSOCIATED WITH cacnb4a HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
episodic ataxia Episodic ataxia, type 5 613855
idiopathic generalized epilepsy {Epilepsy, idiopathic generalized, susceptibility to, 9} 607682
{Epilepsy, juvenile myoclonic, susceptibility to, 6} 607682
GENE ONTOLOGY
Ontology GO Term
Biological Process epiboly involved in gastrulation with mouth forming second (more)
Cellular Component voltage-gated calcium channel complex (more)
Molecular Function voltage-gated calcium channel activity (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000584 (1)
  • InterPro:IPR001452 (1)
  • InterPro:IPR008079 (1)
  • InterPro:IPR008145 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS50002 (1)
  • Pfam:PF00625 (1)
  • Pfam:PF12052 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cacnb4a-001 (1) 1568
    cacnb4a-002 (1) 1497
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacnb4a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cacnb4a Contained in: [BAC] DKEY-219C10 (order this)
    cacnb4a Encodes: [cDNA] MGC:198320 (1) (order this), MGC:198324 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001113519 (1) 2446 bp
    Genomic GenBank:BX548038 (1) 173526 bp
    Select Tool
    Polypeptide UniProtKB:B0F0D0 (1) 519 aa
    Sequence Clusters UniGene:116506 (1)
    Sequence Information (all 25)
    OTHER cacnb4a GENE PAGES
  • Gene:562422 (1)
  • VEGA:OTTDARG00000025898 (1)
  • Ensembl(Zv9):ENSDARG00000009738 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cacnb4a 9  
    Human CACNB4 2 (2q22-q23)
  • OMIM:601949
  • Gene:785
  • Mouse Cacnb4 2 ( 29.98 cM)
  • MGI:103301
  • Gene:12298
  • Orthology Details
    CITATIONS (14)