ZFIN ID: ZDB-GENE-080320-2
Gene Name: calcium channel, voltage-dependent, beta 4a subunit
Gene Symbol: cacnb4a    Nomenclature History

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Previous Names: CAB4a (1), cacnb4.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have high voltage-gated calcium channel activity. Involved in epiboly involved in gastrulation with mouth forming second. Predicted to localize to voltage-gated calcium channel complex. Is expressed in several structures, including cardiovascular system; nervous system; pleuroperitoneal region; presumptive neural retina; and spinal cord neural tube. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and idiopathic generalized epilepsy 9. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4).
Genome Resources: Alliance (1),  Gene:562422 (1),  Ensembl(GRCz11):ENSDARG00000009738 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34703 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cacnb4a N/A 1
    DISEASE ASSOCIATED WITH cacnb4a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    episodic ataxia type 5 Alliance Episodic ataxia, type 5 613855
    idiopathic generalized epilepsy 9 Alliance {Epilepsy, idiopathic generalized, susceptibility to, 9} 607682
    {Epilepsy, juvenile myoclonic, susceptibility to, 6} 607682
    DISEASE ASSOCIATED WITH cacnb4a VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cacnb4a-202 (1)    Ensembl 1568
    cacnb4a-203 (1)    Ensembl 1497
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacnb4a No data available
    MARKER RELATIONSHIPS
    cacnb4a Contained in: [BAC] DKEY-219C10 (order this)
    cacnb4a Encodes: [cDNA] MGC:198320 (1), MGC:198324 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001113519 (1) 2450 nt
    Genomic GenBank:BX548038 (1) 173526 nt
    Select Tool
    Polypeptide UniProtKB:B0F0D0 (1) 519 aa
    Sequence Information (all 25)
    ORTHOLOGY for cacnb4a ( Chr: 9 )
    CITATIONS (20)