Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-080320-2
Gene Name: calcium channel, voltage-dependent, beta 4a subunit
Gene Symbol: cacnb4a
Previous Names: CAB4a (1), cacnb4.2 (1)
Location: Chr: 9   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
  atrium, blastoderm, brain, cerebellum (all 27) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-cacnb4a (1)
PHENOTYPE
Data: 2 figures from Ebert et al., 2008
Observed in: central nervous system, epiboly involved in gastrulation with mouth forming second, marginal blastomere, whole organism (all 5) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Episodic ataxia, type 5 613855
{Epilepsy, idiopathic generalized, susceptibility to, 9} 607682
{Epilepsy, juvenile myoclonic, susceptibility to, 6} 607682
GENE ONTOLOGY
Ontology GO Term
Biological Process epiboly involved in gastrulation with mouth forming second (more)
Cellular Component voltage-gated calcium channel complex (more)
Molecular Function voltage-gated calcium channel activity (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000584 (1)
  • InterPro:IPR001452 (1)
  • InterPro:IPR008079 (1)
  • InterPro:IPR008145 (1)
  • InterPro:IPR027417 (1)
  • PROSITE:PS50002 (1)
  • Pfam:PF00625 (1)
  • Pfam:PF12052 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA cacnb4a-001 (1) 1568
    cacnb4a-002 (1) 1497
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacnb4a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    cacnb4a Contained in: [BAC] DKEY-219C10
    cacnb4a Encodes: [cDNA] MGC:198320 (1) (order this), MGC:198324 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001113519 (1) 2446 bp
    Genomic GenBank:BX548038 (1) 173526 bp
    Select Tool
    Polypeptide UniProtKB:B0F0D0 (1) 519 aa
    Sequence Clusters UniGene:116506 (1)
    Sequence Information (all 25)
    OTHER cacnb4a GENE PAGES
  • Gene:562422 (1)
  • VEGA:OTTDARG00000025898 (1)
  • Ensembl(Zv9):ENSDARG00000009738 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish cacnb4a 9  
    Human CACNB4 2 (2q22-q23)
  • OMIM:601949
  • Gene:785
  • Mouse Cacnb4 2 ( 29.98 cM)
  • MGI:103301
  • Gene:12298
  • Orthology Details
    CITATIONS (13)